Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. BackgroundThe utilisation of vasoconstrictors like clonidine with local anaesthetics during subarachnoid blockade is a well-established practice.PurposeThis study aims to compare the effects of oral clonidine premedication versus placebo on the onset and …Read Original Source

Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. BackgroundCancer is a complex condition defined by the uncontrolled growth and proliferation of cells. Brain neoplasms, both primary and secondary, present a rising global health burden. Newer classification integrates key molecular markers; IDH mutation, …Read Original Source

Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. BackgroundIn Serbia, as well as worldwide, clinical trials are a significant and unavoidable part of the development of new medicines. There is limited research on prospective risk management in clinical trials in Serbia, underscoring the need for …Read Original Source

Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. A case of colchicine overdose of 27 mg, or 0.27 mg/kg (weight 99.8 kg), is reported to assess the potential symptoms seen with this type of toxicity and analyze a prospective treatment for successful outcomes. A 74-year-old man unintentionally ingested …Read Original…

Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. BackgroundAutoimmune and inflammatory diseases, such as rheumatoid arthritis, multiple sclerosis, inflammatory bowel disease, and psoriasis, are typified by immune dysregulation resulting in chronic inflammation and progressive tissue injury. Standard …Read Original Source

Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. BackgroundSickle cell anemia is a monogenic hemoglobinopathy caused by a mutation in the β-globin gene (hemoglobin subunit beta, HBB), leading to the production of hemoglobin S (HbS). Under deoxygenated conditions, HbS polymerizes abnormally, causing red …Read Original Source

Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. BackgroundNoni (Morinda citrifolia Linn.) fruit has a long history of traditional use for treating several health conditions, including symptoms of major depression and anxiety.PurposeThis study focused on evaluating the therapeutic potential of the …Read Original Source

Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. BackgroundWe have reported that the renal kallikrein–kinin system is involved in the diuretic action of potassium or furosemide in rats.PurposeThe aim of this study was to investigate whether the renal kallikrein–kinin system is involved in the diuretic …Read Original Source