RESEARCH PAPER
Year : 2010  |  Volume : 1  |  Issue : 1  |  Page : 38-41

Free radical scavenging property and diuretic effect of triglize, a polyherbal formulation in experimental models


1 Department of Pharmacology, JIPMER, Pondicherry, India
2 TIFAC-CORE, J.S.S College of Pharmacy, Ootacamund, India
3 Green Milk Concepts, Herbal Division of Apex Laboratories, Chennai - 600 038, India

Correspondence Address:
S Parasuraman
Department of Pharmacology, JIPMER, Pondicherry
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0976-500X.64535

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Objective: To determine the in vitro free radical scavenging property and in vivo diuretic effect of Triglize TM , a marketed polyherbal formulation in experimental models. Materials and Methods: The aqueous extract of polyherbal formulation (PHF) triglize was used for the experiment. The free radical scavenging property and antioxidant effect of PHF were studied by LPS-induced free radicals in rat macrophages cells and DPPH (2, 2-Diphenyl-1-Picrylhydrazyl) methods, respectively. The diuretic effect of a PHF was studied with Lipschitz model using male Wistar rats. Results: PHF significantly inhibited lipopolysaccharide -induced free radicals in rat macrophages and it showed moderate antioxidant potential in DPPH model. Polyherbal formulation at 50, 200 and 400 mg/ kg significantly increased potassium excretion in urine at 0-5 h and 5-24 h. The diuretic effect of PHF was as similar as furosemide. Conclusion: The PHF has significant diuretic effect and free radical scavenging properties.


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