RESEARCH PAPER
Year : 2011  |  Volume : 2  |  Issue : 2  |  Page : 90-94

Effect of ormeloxifene, a nonsteroidal once-a-week oral contraceptive, on systemic hemodynamics in adult female rats


1 Department of Pharmacology, Subharti Medical College, Meerut, India
2 Department of Pharmacology and Therapeutics, CSM Medical University, Lucknow, India
3 Department of Pharmacology, Central Drug Research Institute, Lucknow, India
4 Saraswati Dental College and Hospital, Faizabad Road, Lucknow, India

Correspondence Address:
Hiralal Bhalla
Department of Pharmacology, Subharti Medical College, Meerut
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0976-500X.81898

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Objective: To investigate the short-term effects of ormeloxifene on systemic hemodynamics, coagulation profile, and serum antioxidant activity in vivo in comparison with raloxifene. Materials and Methods: Colony-bred adult female Sprague-Dawley rats were randomized into 19 groups of 10 each and received either ormeloxifene or raloxifene (0.25, 1.25, or 3 mg/kg/day) for 7, 15, or 30 days by the oral route. Animals of control group received vehicle (gum-acacia in distilled water) alone in a similar manner. Systemic hemodynamics and serum total antioxidant activity were assessed 24 h after the last treatment. Results: There was no significant effect of ormeloxifene administered at these doses and schedules on hemodynamic parameters or antioxidant activity, except for increase in amplitude of R wave in rats treated with 3 mg/kg/day dose for 30 days. This effect with raloxifene was evident only 7 days after treatment at this dose. Overall response was, however, almost similar with both the agents. Conclusion: The findings demonstrate comparable pharmacological profile of ormeloxifene and raloxifene on short-term administration to rats. Based on changes observed in the ECG (R wave), long-term studies may lead to justifiable comparison of beneficial and harmful effects of ormeloxifene and raloxifene in relation to cardiovascular effects.


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