RESEARCH PAPER
Year : 2012  |  Volume : 3  |  Issue : 1  |  Page : 39-42

Acute effects of granulocyte colony-stimulating factor on early ventricular arrhythmias after coronary occlusion in rats


Department of Physiological Sciences, Federal University of Espírito Santo, Vitória, ES, Brazil

Correspondence Address:
Marcelo Perim Baldo
Department of Physiological Sciences, Federal University of Espirito Santo, Av. Marechal Campos, 1468 - 29042-751, Vitoria, ES
Brazil
Login to access the Email id

Source of Support: Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) and Fundação de Amparo a Pesquisa do Espírito Santo (FAPES/PRONEX), Conflict of Interest: None


DOI: 10.4103/0976-500X.92508

Rights and Permissions

Objectives: To evaluate the acute effects of colony-stimulating factor (G-CSF) on ventricular arrhythmias after coronary occlusion in rats. Materials and Methods: Male Wistar rats (10 weeks) received G-CSF (100 μg.kg -1 ) or vehicle. Thirty minutes later, animals were infarcted by coronary occlusion under artificial respiration. Electrocardiogram was monitored for 30 min to evaluate ventricular arrhythmias. Results: G-CSF treatment reduced the number of premature ventricular beats and the number and duration of ventricular tachycardia. The incidence of ventricular fibrillation was significantly reduced by G-CSF (MI-Cont: 11.2 ± 2.4 vs. MI-GCSF: 5.4 ± 1 events; P < 0.05). However, total duration of ventricular fibrillation was not altered (MI-Cont: 84 ± 16 vs. MI-GCSF: 76 ± 13 sec). Conclusions: Acute administration of G-CSF before coronary ligature in rats reduces the incidence of ventricular premature beats and ventricular tachycardia, suggesting a possible direct electrophysiological effect of this cytokine independently of its genomic effects. However, the data suggest that G-CSF treatment may affect the spontaneous recovery from ventricular fibrillation. Acute G-CSF administration acts directly on cardiac electrophysiology, different from chronic treatment.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1767    
    Printed126    
    Emailed0    
    PDF Downloaded325    
    Comments [Add]    
    Cited by others 3    

Recommend this journal