RESEARCH PAPER
Year : 2012  |  Volume : 3  |  Issue : 2  |  Page : 138-142

Patient factors impacting antiretroviral drug adherence in a Nigerian tertiary hospital


1 Department of Pharmacology, Faculty of Pharmaceutical Sciences, University of Jos/APIN Centre, Jos, Nigeria
2 Department of Pharmacy, University Teaching Hospital, Jos, Nigeria
3 Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, University of Jos, Jos, Nigeria

Correspondence Address:
Kakjing D Falang
Department of Pharmacology, Faculty of Pharmaceutical Sciences, University of Jos/APIN Centre, Jos University Teaching Hospital, Jos
Nigeria
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0976-500X.95511

Rights and Permissions

Objective: To study the adherence levels and explore factors impacting them in out-patients on antiretroviral therapy (ART) at the AIDS Prevention Initiative in Nigeria antiretroviral clinic of the Jos University Teaching Hospital. Materials and Methods: We administered a structured questionnaire to 461 patients presenting to the clinic. Adherence was measured using the patient self-report. The association between independent variables and adherence to ART was measured through odd ratios (OR) in the univariate analysis. The best predictors of adherence were determined through multiple logistic regression models with backward elimination. Results: The adherence level was found to be 87.9%. The following factors were found to have strong impact on adherence in the univariate analysis: age (OR 1.04), sex (OR 1.14), employment (OR 1.29), knowledge of HIV (OR 1.11), thrice daily frequency of drug intake (OR 1.68), twice daily frequency (OR 2.18), alcohol nonintake (OR 0.29), knowledge of ARVs (OR 1.23), pill burden (OR 1.20), and HIV status disclosure (OR 1.08). In the multivariate analysis, only age, alcohol nonintake and twice daily, frequency of drug intake affected adherence (P < 0.05). Conclusions: To increase adherence and the effectiveness of ART, there is need to continuously emphasize the use of adherence devices and reminders. Counseling and adherence education should also be emphasized especially for younger patients and those with low educational levels.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1790    
    Printed162    
    Emailed0    
    PDF Downloaded384    
    Comments [Add]    
    Cited by others 2    

Recommend this journal