RESEARCH PAPER
Year : 2012  |  Volume : 3  |  Issue : 2  |  Page : 143-148

Cardiorenal benefits of early versus late cyclosporine to sirolimus conversion in a rat model


1 Laboratory of Pharmacology and Experimental Therapeutics, IBILI, Medicine Faculty, Coimbra University, Coimbra, Portugal
2 Laboratory of Pharmacology and Experimental Therapeutics, IBILI, Medicine Faculty, Coimbra University; Department of Urology and Renal Transplantation, Coimbra University Hospital, Coimbra, Portugal
3 Center for Neuroscience and Cell Biology, Coimbra, Portugal

Correspondence Address:
Flávio Reis
Laboratory of Pharmacology and Experimental Therapeutics, IBILI, Medicine Faculty, Sub-Unit 1 (Pólo 3), Coimbra University, 3000-548 Coimbra
Portugal
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0976-500X.95513

Rights and Permissions

Objective: To compare the cardiorenal effects of early versus late cyclosporine (CsA) to sirolimus (SRL) conversion, using a novel animal model that mimics these protocols used in the clinical practice, and focusing on blood pressure, heart rate (HR), biochemical data and heart and kidney lipid peroxidation. Materials and Methods: The study had five groups. Six male Wistar rats in each group were used during a 9-week study protocol: control, CsA (5 mg/kg/day), SRL (1 mg/kg/day); early conversion and late conversion. Cardiorenal evaluation was assessed by biochemical data, blood pressure, HR, and heart and kidney lipid peroxidation. Results: As expected, CsA promoted cardiorenal impairment, viewed by development of hypertension, tachycardia, increased urea, creatine kinase, and glucose levels, as well as heart and kidney oxidative stress. SRL, as expected, promoted less cardiorenal side effects, namely those related with nephrotoxicity. In agreement, both early and late conversions from CsA to SRL produced less side-effects, namely those related to the CsA-induced nephrotoxicity. Conclusions: In our model, both early and late CsA to SRL conversion promoted amelioration of the CsA -induced cardiorenal damage. However, early substitution seems to produce more benefits, in particular due to higher improvement of the cardiac profile.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1678    
    Printed140    
    Emailed0    
    PDF Downloaded315    
    Comments [Add]    

Recommend this journal