RESEARCH PAPER
Year : 2013  |  Volume : 4  |  Issue : 1  |  Page : 39-46

Efficacy and safety of Tinospora cordifolia lotion in Sarcoptes scabiei var hominis-infected pediatric patients: A single blind, randomized controlled trial


1 Faculty of Pharmacy, University of Santo Tomas, Manila, Philippines
2 The Graduate School, University of Santo Tomas, Manila, Philippines
3 The Graduate School, University of Santo Tomas, Manila; College of Science, University of Santo Tomas, Manila, Philippines
4 Institute of Pediatrics and Child Health, Manila, Philippines
5 Department of Internal Medicine, St. Luke's Medical Center, Manila, Philippines
6 Department of Emergency Medicine, St. Luke's Medical Center, Manila, Philippines

Correspondence Address:
Agnes L Castillo
Faculty of Pharmacy, University of Santo Tomas, Sampaloc 1015, Manila
Philippines
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0976-500X.107668

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Objective: To evaluate the clinical efficacy and safety of Tinospora cordifolia lotion including its cure rate and clearance time compared with permethrin lotion . Materials and Methods: A single blind, randomized, controlled, pilot clinical study was performed in three government institutions to investigate clinical efficacy of T.cordifolia lotion in sixty-six clinically-diagnosed scabies-infected patients. The patients were treated with T.cordifolia or permethrin lotions for three consecutive days for two weeks and clinical assessment of each patient was performed for five weeks. Results: T. cordifolia lotion and permethrin significantly reduced the mean global evaluation score after four weeks of treatment. The two lotions showed comparable effects as anti-scabies agent. Moreover, the clearance time (days) and cure rate using the two lotions did not differ. Clinical improvement, mean clearance time and cure rate of T.cordifolia lotion are comparable with permethrin . Conclusions: Tinospora cordifolia lotion exhibits anti-scabies activity comparable with permethrin. Its incorporation as therapeutic reagent in Sarcoptes scabiei infections is highly recommended.


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