RESEARCH PAPER
Year : 2013  |  Volume : 4  |  Issue : 4  |  Page : 238-242

Anti-inflammatory activity of calcium channel blocker lercanidipine hydrochloride


Department of Anatomy, Sri Manakula Vinayagar Medical College and Hospital, Puducherry, India

Correspondence Address:
Mounissamy Batmanabane
7, Main Road, Thiru Nagar, Moolakulam, Puducherry
India
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Source of Support: Study supported by ICMR STS to PV, Conflict of Interest: None


DOI: 10.4103/0976-500X.119707

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Objective: To evaluate the anti-inflammatory effect of the third-generation CCB, lercanidipine. Materials and Methods: The ability of lercanidipine to reduce inflammation in carrageenan-induced paw edema in rats was evaluated, using different doses and its anti-inflammatory effect was compared with that of diclofenac sodium. Mast cell degranulation effect of lercanidipine was also carried out. Results: Lercanidipine produced a significant reduction in the inflammatory paw edema at all doses and at all intervals (P < 0.001). The percentage of reduction in edema was found to be proportionate to the doses of lercanidipine. Lercanidipine also significantly reduced the percentage of propranolol-induced mast cell degranulation. Conclusions: It was found that lercanidipine exerts a positive anti-inflammatory effect in a dose-dependent manner and was superior to diclofenac sodium.


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