RESEARCH PAPER
Year : 2013  |  Volume : 4  |  Issue : 4  |  Page : 247-255

Evaluation of a new computerized psychometric test battery: Effects of zolpidem and caffeine


Department of Clinical Pharmacology and Therapeutics, ICMR Advanced Centre for Clinical Pharmacodynamics, Nizam's Institute of Medical Sciences, Panjagutta, Hyderabad, India

Correspondence Address:
Raveendranadh Pilli
Department of Clinical Pharmacology and Therapeutics, ICMR Advanced Centre for Clinical Pharmacodynamics, Nizam's Institute of Medical Sciences, Panjagutta, Hyderabad
India
Login to access the Email id

Source of Support: Indian Council of Medical Research, New Delhi, India for the financial support [Grant No: 44/7/2000/BMS] and facilities to carry out this study. Suraksha Pharmaceuticals Ltd, Roorkee, India, for providing study medication, Conflict of Interest: None


DOI: 10.4103/0976-500X.119710

Rights and Permissions

Objective: To evaluate the effects of centrally active drugs using a new indigenously developed automated psychometric test system and compare the results with that obtained using pencil- and paper-based techniques. Materials and Methods: The tests were standardized in 24 healthy participants. Reproducibility of the test procedure was evaluated by performing the tests by a single experimenter on two occasions (interday reproducibility). To evaluate the sensitivity of the tests, the effects of zolpidem (5 mg) and caffeine (500 mg) versus placebo were studied in 24 healthy participants in a randomized, double-blind three-way crossover design. Results: Psychometric tests were performed at baseline and at 1, 2, and 3 h after administration of study medication. The effects of zolpidem and caffeine on the psychomotor performance were most pronounced 1 h after administration. At this time, a significant impairment of performance in the simple reaction test (SRT), choice discrimination test (CDT), digit symbol substitution test (DSST), digit vigilance test (DVT), and card sorting test (CST) was observed with zolpidem. In contrast, caffeine showed a significant improvement in performance in CDT and DVT only. Conclusion: The results suggest that the tests of the computerized system are more sensitive and reliable then the pencil and paper tests in detecting the effects of central acting agents and are suitable for use in clinical areas to conduct studies with patients.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1961    
    Printed73    
    Emailed1    
    PDF Downloaded335    
    Comments [Add]    
    Cited by others 2    

Recommend this journal