CASE REPORT
Year : 2013  |  Volume : 4  |  Issue : 4  |  Page : 300-302

A rare case of ethambutol induced pulmonary eosinophilia


1 Department of Pulmonary Medicine, Burdwan Medical College and Hospital, Burdwan, India
2 Department of Pulmonary Medicine, R G Kar Medical College, Kolkata, India
3 Department of Pulmonary Medicine, NRS Medical College and Hospital, Shealdah, Kolkata, West Bengal, India

Correspondence Address:
Kaushik Saha
Rabindra Pally, 1st Lane, P.O. - Nimta, Kolkata - 700 049, West Bengal
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0976-500X.119724

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Antitubercular drug (ATD) induced eosinophilic lung disease is a rare phenomenon. It usually occurs due to isoniazid and para amino salicylic acid. A 34-year-male of sputum positive pulmonary tuberculosis, on antitubercular drugs (rifampicin, isoniazid, ethambutol, and pyrazinamide) for last 3 weeks, presented with generalized arthralgia and maculopapular rash for last 2 weeks and shortness of breath for last 1 week. Chest X-ray and High resolution computerized tomographic scan thorax showed bilateral peripheral airspace opacification. Bronchoalveolar lavage revealed 51% eosinophils of total cellularity (1200/cmm) confirming the diagnosis of pulmonary eosinophilia. ATD was stopped for 2 weeks and then reintroduced one by one. Patient again developed similar kind of symptoms with reintroduction of ethambutol. According to criteria for drug induced pulmonary eosinophilia, he was diagnosed as a case of ethambutol induced pulmonary eosinophilia.


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