RESEARCH PAPER
Year : 2014  |  Volume : 5  |  Issue : 3  |  Page : 193-196

Effects of glucocorticoids and tumor necrosis factor-alpha inhibitors on both clinical and molecular parameters in patients with Takayasu arteritis


1 Department of Medical and Surgical Science, Interuniversity Center of Phlebolymphology, International Research and Educational Program in Clinical and Experimental Biotechnology, Catanzaro, Italy
2 Department of Surgery, Unit of Vascular Surgery, Annunziata Hospital of Cosenza, Cosenza, Italy
3 Department of Pharmacological, Biological and Chemical Science, University of Parma, Parma, Italy
4 Department of Health Science, University Magna Graecia of Catanzaro, Catanzaro, Italy

Correspondence Address:
Luca Gallelli
Department of Health Science, University Magna Graecia of Catanzaro, Viale Europa, Località Germaneto 88100, Catanzaro
Italy
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0976-500X.136101

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Objective: To explore the effect of sequential treatment with glucocorticoid and tumor necrosis factor-alpha inhibitors in patients with Takayasu arteritis (TA). Materials and Methods: In five patients with TA, the effects of the sequential treatment with prednisone for 5-7 months and then with adalimumab (ADA) + methotrexate (MTX) or infliximab + MTX, or with ADA only, for 12 months on both clinical and laboratory findings were evaluated. Results: All treatments improved both symptoms and laboratory parameters without the development of side-effects. Conclusions: It was hypothesized that MMP-9 and neutrophil gelatinase-associated lipocalin could be markers of the response to the treatments.


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