RESEARCH PAPER
Year : 2014  |  Volume : 5  |  Issue : 4  |  Page : 239-244

Oral carvedilol in escalating doses in the acute treatment of atrial fibrillation


Department of Cardiology, Andhra Medical College, King George Hospital, Visakhapatnam, Andhra Pradesh, India

Correspondence Address:
Ravi Venkatachelam Chitrapu
Department of Cardiology, Andhra Medical College, King George Hospital, Visakhapatnam - 530 002, Andhra Pradesh
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0976-500X.142430

Clinical trial registration REF/2014/06/007054

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Objective: To study the efficacy of oral carvedilol in acute treatment of atrial fibrillation (AF) with fast ventricular rate. Materials and Methods: In an open-label, single-arm trial, oral carvedilol was administered to 35 patients of AF in escalating doses from 3.125 mg o.d. to 12.5 mg b.i.d. Results: A successful result was seen in 25 patients (71.4%) with 4 converting to sinus rhythm, rate control to less than 90 bpm in 16 and a 20% rate reduction in 5 patients. Two patients developed hypotension needing withdrawal of the drug. Conclusion: Escalating doses of oral carvedilol can be effectively and safely used in the acute treatment of AF with fast ventricular rate.


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