RESEARCH PAPER
Year : 2015  |  Volume : 6  |  Issue : 3  |  Page : 142-146

Effectiveness of vitamin D3 in severe persistent asthmatic patients: A double blind, randomized, clinical study


1 Department of Pharmacy Practice, Faculty of Pharmacy, Sri Ramachandra University, Porur, Chennai, Tamil Nadu, India
2 Department of Pulmonary Medicine, SRM Medical College Hospital and Research Center, SRM University, Kattankulathur, Tamil Nadu, India
3 Department of Community Medicine, ESIC PGIMSR Medical College, KK Nagar, Chennai, Tamil Nadu, India

Correspondence Address:
Arcot D Nageswari
Department of Pulmonary Medicine, SRM Medical College Hospital and Research Centre, SRM University, Kancheepuram, Kattankulathur - 603 203, Tamil Nadu
India
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Source of Support: Nil., Conflict of Interest: There are no conflicts of interest.


DOI: 10.4103/0976-500X.162022

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Objective: To assess the pulmonary function and quality of life in asthma patients receiving vitamin D3 supplementation with inhaled budesonide and formoterol. Materials and Methods: This was a double blinded, randomized, comparative study. Patients were recruited as per the study criteria and randomized into two groups: usual care group (n = 69) patients received budesonide (800 μg) with formoterol (24 μg) and intervention care group (n = 72) patients received vitamin D3 (1000 IU) supplementation along with budesonide (800 μg) plus formoterol (24 μg) for a period of 6 months. Results: A total of 140 patients completed the study. Significant within-group improvement and non-significant between-group improvement is observed with respect to FEV1. In terms of health-related quality of life, within-group comparison revealed a significant (P < 0.05) improvement in all the domains of SGRQ. However, between-group comparisons showed statistically significant (P < 0.05) improvement in symptom, impact and total scores. Conclusion: On the basis of our findings, we conclude that supplementation of vitamin D3 is effective in improving the quality of life rather than pulmonary function in severe asthmatics. However, further studies are warranted to substantiate the present findings.


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