RESEARCH PAPER
Year : 2016  |  Volume : 7  |  Issue : 2  |  Page : 80-86

Effect of losartan and atenolol on insulin sensitivity in nondiabetic hypertensive patients


1 Department of Pharmacology, SMBT Institute of Medical Sciences and Research Centre, Dhamangaon, Nashik, Maharashtra, India
2 Department of Pharmacology, Armed Forces Medical College, Pune, Maharashtra, India

Correspondence Address:
Sandesh Madhukar Bharati
Department of Pharmacology, SMBT Institute of Medical Sciences and Research Centre, Nandi Hills, Dhamangaon-Ghoti, Igatpuri, Nashik - 422 403, Maharashtra
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0976-500X.184771

Rights and Permissions

Objective: To study the effects of losartan and atenolol on glucometabolic parameters in nondiabetic hypertensive patients. Materials and Methods: In a prospective, open-label, parallel group study, nondiabetic patients with mild to moderate hypertension were randomized to either losartan (titrated from 50 to 100 mg/day, n = 20) or atenolol (titrated from 25 mg to 100 mg/day, n = 20) for period of 24 weeks. At baseline, 12 and 24 weeks fasting plasma glucose (FPG), fasting plasma insulin (FPI), homeostasis model assessment for insulin resistance (HOMA-IR) apart from lipid parameters, mean systolic, and diastolic blood pressures levels were determined. Results: At the end of study, losartan significantly (P < 0.05) reduced FPG, FPI, and HOMA-IR compared to atenolol and baseline. While atenolol increased the HOMA-IR levels significantly compared to the baseline. Conclusions: Losartan improved the insulin sensitivity while atenolol worsened it. Losartan is better than atenolol for its effects on the glucose-insulin metabolism.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1796    
    Printed45    
    Emailed0    
    PDF Downloaded604    
    Comments [Add]    
    Cited by others 1    

Recommend this journal