RESEARCH PAPER
Year : 2017  |  Volume : 8  |  Issue : 1  |  Page : 21-27

Antianginal efficacy and tolerability of ranolazine as an add-on drug to concomitant medications primarily metoprolol in chronic stable angina patients: A prospective, open-label study


1 Department of Pharmacology, BLDEU's Shri B. M. Patil Medical College and RC, Vijayapura, Bengaluru, Karnataka, India
2 Department of Pharmacology, M. S. Ramaiah Medical College, Bengaluru, Karnataka, India
3 Department of Cardiology, M. S. Ramaiah Medical College, Bengaluru, Karnataka, India

Correspondence Address:
Anant Mahaveer Khot
Department of Pharmacology, BLDEU's Shri B. M. Patil Medical College and RC, Vijayapura - 586 103, Karnataka
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jpp.JPP_168_16

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Objective: To evaluate the efficacy and tolerability of ranolazine as an add-on drug in chronic stable angina patients and the impact of ranolazine on the quality of life in chronic stable angina patients receiving other antianginal medications. Materials and Methods: It was a prospective, open-label, hospital-based study involving 144 patients with chronic stable angina. First group received either metoprolol 12.5 or 25 mg/day or other antianginal medications; if the symptoms persist, the dose of metoprolol was increased to 50 mg/day, and to the second group, ranolazine 500 mg BD or 1 g OD was added along with metoprolol or others if the anginal attacks were not subsiding. The patients were followed up to 6 months with electrocardiography, treadmill test, and quality of life questionnaire. Adverse events were recorded at each visit during the study. Results: There was a statistically significant reduction in weekly anginal frequency (P < 0.001) and improvement in an exercise tolerance in both the groups, but more in the ranolazine group. Adverse events reported were mild, infrequent. Conclusion: Ranolazine is could be used as an add-on drug in chronic angina patients not improved with metoprolol or antianginal medications.


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