RESEARCH PAPER
Year : 2017  |  Volume : 8  |  Issue : 2  |  Page : 50-53

Efficacy of atorvastatin in prevention of contrast-induced nephropathy in high-risk patients undergoing angiography: A double-blind randomized controlled trial


1 Department of Pharmacology, Indian Institute of Medical Science and Research and Noor Hospital, Jalna, Maharashtra, India
2 Department of Pharmacology, Government Medical College and Hospital, Aurangabad, Maharashtra, India
3 Department of Pharmacology, People's College of Medical Sciences and Research Centre, Bhopal, Maharashtra, India
4 Department of Pharmacology, Byramjee Jeejeebhoy Government Medical College and Sassoon General Hospital, Pune, Maharashtra, India

Correspondence Address:
Maaz Hussain Syed
H No: 4-9-72, Ranmast Pura, Jinsi Road, Aurangabad - 431 001, Maharashtra
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jpp.JPP_156_16

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Objective: To evaluate the efficacy and safety of atorvastatin (ATN) 80 mg in the prevention of contrast medium- induced nephropathy (CIN) in high risk patients undergoing angiograph. Materials and Methods: This was a prospective, double-blind, two-arm, parallel group RCT. A total of 216 patients undergoing coronary angiography were screened, and 188 eligible patients were randomized to two treatment arms. Patients in Group A received tablet N-acetylcysteine (NAC) 1200 mg once daily, and patients in Group B received tablet atorvastatin 80 mg + NAC 1200 mg once daily, for 3 days before, and 2 days after angiography. Results: A total of 160 patients completed the trial. Postprocedure, nine and two CIN cases were found in Group A and B, respectively. The mean change in serum creatinine was 0.086 ± 0.168 in Group A and 0.021 ± 0.083 in Group B, which was statistically significant (P = 0.0289). Postprocedure, the estimated glomerular filteration rate was reduced by 19.52 in Group A and 13.55 in Group B (P = 0.003). Conclusion: This trial indicates the positive role of statins in preventive strategy against CIN along with NAC.


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