|Year : 2018 | Volume
| Issue : 1 | Page : 42
Does mirtazapine withdrawal induces mania or not?
Kamaldeep Sadh1, Pooja Shatadal2, Ekta Franscina Pinto3, Sachin Nagendrappa4, Harish M Tharayil5, Chittaranjan Andrade3
1 Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India
2 Government Medical College, Surat, Gujarat, India
3 Department of Psychopharmacology, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India
4 National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India
5 Department of Psychiatry, Government Medical College, Kozhikode, Kerala, India
|Date of Submission||07-Mar-2018|
|Date of Decision||04-Jul-2018|
|Date of Acceptance||05-Jun-2018|
|Date of Web Publication||11-Jul-2018|
Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bengaluru - 560 029, Karnataka
Source of Support: None, Conflict of Interest: None
|How to cite this article:|
Sadh K, Shatadal P, Pinto EF, Nagendrappa S, Tharayil HM, Andrade C. Does mirtazapine withdrawal induces mania or not?. J Pharmacol Pharmacother 2018;9:42
|How to cite this URL:|
Sadh K, Shatadal P, Pinto EF, Nagendrappa S, Tharayil HM, Andrade C. Does mirtazapine withdrawal induces mania or not?. J Pharmacol Pharmacother [serial online] 2018 [cited 2019 Jul 18];9:42. Available from: http://www.jpharmacol.com/text.asp?2018/9/1/42/236321
Pombo et al. reported a 26-year-old male who stopped taking mirtazapine 4 days before death, resulting from violence associated with sudden-onset abnormal behavior. The authors concluded that the abnormal behavior was mania induced by mirtazapine withdrawal, as confirmed at autopsy by very low levels of mirtazapine and its metabolite in blood.
We are deeply concerned by these conclusions. First, there is not a shred of evidence presented by the authors that supports the diagnosis of mania. Given the history of schizophreniform disorder and cannabis abuse, the patient may well have had a nonaffective psychotic relapse that may or may not have been related to cannabis. Next, early cognitive-behavioral changes associated with relapse into psychosis may have been responsible for mirtazapine discontinuation, rather than mirtazapine discontinuation having been responsible for psychosis onset. A mere temporal succession of events does not establish a cause–effect relationship. In this context, would discontinuation of cannabis and finding low levels of cannabis in the blood establish cannabis as a cause of the psychosis?
Finally, we are particularly concerned by the sensationalism in the title and the hyperbole in the concluding sentence of the discussion. Flawed interpretation of events and exaggerated recommendations can be amplified by the media and can harm patient sentiments. The measles, mumps, and rubella vaccine story is an excellent example of how much public health damage a single irresponsible paper can cause.
Declaration of patient consent
The authors certify that they have obtained all appropriate patient consent forms. In the form the patient(s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.
Financial support and sponsorship
Conflicts of interest
There are no conflicts of interest.
| References|| |
Pombo R, Johnson E, Gamboa A, Omalu B. Autopsy-proven mirtazapine withdrawal-induced mania/hypomania associated with sudden death. J Pharmacol Pharmacother 2017;8:185-7.
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Rao TS, Andrade C. The MMR vaccine and autism: Sensation, refutation, retraction, and fraud. Indian J Psychiatry 2011;53:95-6.