RESEARCH PAPER
Year : 2020  |  Volume : 11  |  Issue : 1  |  Page : 13-18

Effect of nebivolol on microalbuminuria in hypertensive patients with or without type 2 diabetes mellitus


1 Department of Pharmacology, Kamineni Academy of Medical Sciences and Research Centre, Hyderabad, Telangana, India
2 Department of General Medicine, Gandhi Medical College/Hospital, Secunderabad, Telangana, India

Correspondence Address:
Thrilok Chander Bingi
Flat No: 605, Namita Everest, Bahadurguda, L.B. Nagar, Ranga Reddy, Hyderabad - 500 074, Telangana
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jpp.JPP_95_19

Rights and Permissions

Objective: To evaluate the effect of nebivolol on microalbuminuria (MA) in hypertensive patients with or without type 2 diabetes mellitus. Materials and Methods: This was an open-label, prospective study. Drug naive patients with stage I hypertension with or without type 2 DM with MA (urine albumin: creatinine ratio [UACR] between 30–300 mg/g) were enrolled in the study and were started on nebivolol 5 mg orally once daily. Efficacy parameters UACR, blood pressure (BP) were measured at baseline and 24 weeks. Paired t-test was used to analyze efficacy endpoints. P < 0.05 was considered to be statistically significant. Results: A total of 30 participants completed the study. Participants who received nebivolol showed a significant decrease in mean UACR, systolic BP, and diastolic BP at 24 weeks compared to baseline (P < 0.001). No participant discontinued the study because of adverse events. Conclusion: Nebivolol has a favorable effect on MA in addition to its antihypertensive effect in hypertensive patients. Further studies with large samples are required to characterize this effect of nebivolol on clinical outcomes.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed151    
    Printed5    
    Emailed0    
    PDF Downloaded58    
    Comments [Add]    

Recommend this journal