Journal of Pharmacology and Pharmacotherapeutics

RESEARCH PAPER
Year
: 2010  |  Volume : 1  |  Issue : 1  |  Page : 38--41

Free radical scavenging property and diuretic effect of triglize, a polyherbal formulation in experimental models


S Parasuraman1, EP Kumar1, Anil Kumar2, SF Emerson3 
1 Department of Pharmacology, JIPMER, Pondicherry, India
2 TIFAC-CORE, J.S.S College of Pharmacy, Ootacamund, India
3 Green Milk Concepts, Herbal Division of Apex Laboratories, Chennai - 600 038, India

Correspondence Address:
S Parasuraman
Department of Pharmacology, JIPMER, Pondicherry
India

Objective: To determine the in vitro free radical scavenging property and in vivo diuretic effect of Triglize TM , a marketed polyherbal formulation in experimental models. Materials and Methods: The aqueous extract of polyherbal formulation (PHF) triglize was used for the experiment. The free radical scavenging property and antioxidant effect of PHF were studied by LPS-induced free radicals in rat macrophages cells and DPPH (2, 2-Diphenyl-1-Picrylhydrazyl) methods, respectively. The diuretic effect of a PHF was studied with Lipschitz model using male Wistar rats. Results: PHF significantly inhibited lipopolysaccharide -induced free radicals in rat macrophages and it showed moderate antioxidant potential in DPPH model. Polyherbal formulation at 50, 200 and 400 mg/ kg significantly increased potassium excretion in urine at 0-5 h and 5-24 h. The diuretic effect of PHF was as similar as furosemide. Conclusion: The PHF has significant diuretic effect and free radical scavenging properties.


How to cite this article:
Parasuraman S, Kumar E P, Kumar A, Emerson S F. Free radical scavenging property and diuretic effect of triglize, a polyherbal formulation in experimental models.J Pharmacol Pharmacother 2010;1:38-41


How to cite this URL:
Parasuraman S, Kumar E P, Kumar A, Emerson S F. Free radical scavenging property and diuretic effect of triglize, a polyherbal formulation in experimental models. J Pharmacol Pharmacother [serial online] 2010 [cited 2020 Feb 26 ];1:38-41
Available from: http://www.jpharmacol.com/article.asp?issn=0976-500X;year=2010;volume=1;issue=1;spage=38;epage=41;aulast=Parasuraman;type=0