Journal of Pharmacology and Pharmacotherapeutics

REVIEW ARTICLE
Year
: 2012  |  Volume : 3  |  Issue : 3  |  Page : 217--227

MicroRNAs as newer therapeutic targets: A big hope from a tiny player


Hardik S Ghelani, Manish A Rachchh, Rina H Gokani 
 Department of Pharmacology, S.J. Thakkar Pharmacy College, Kalawad Road, Rajkot, Gujarat, India

Correspondence Address:
Rina H Gokani
DQShree KunjDQ, 3 Archna Park Society, B/H Krishna Complex, University Road, Rajkot 360 005, Gujarat
India

MicroRNAs (miRNAs) are a novel group of universally present small noncoding endogenous RNAs that regulate gene expression and protein coding by base pairing with the 3′ untranslated region (UTR) of target mRNAs. So they have been associated with several physiological processes and play an important role in the manifestation of diverse diseases. miRNAs expression is associated with the normal and diverse pathophysiological state including cardiac hypertrophy, neurodegenerative diseases, diabetes and its complication, and cancer because individual miRNAs are associated with the regulation of the expression of multiple target genes. Modulating the expression of a single miRNA can influence an entire gene network and thereby modify complex disease phenotypes. From recent studies, it has been confirmed that miRNA has a potential physiological role in various body systems. But in some specialized condition over expression of miRNA within the cytoplasm also leads to some pathological condition in the body. Here, we summarize the roles of miRNAs in various pathological conditions and consider the advantages and potential challenges of miRNA-based therapeutic approaches compared to conventional drug-based therapies.


How to cite this article:
Ghelani HS, Rachchh MA, Gokani RH. MicroRNAs as newer therapeutic targets: A big hope from a tiny player.J Pharmacol Pharmacother 2012;3:217-227


How to cite this URL:
Ghelani HS, Rachchh MA, Gokani RH. MicroRNAs as newer therapeutic targets: A big hope from a tiny player. J Pharmacol Pharmacother [serial online] 2012 [cited 2020 Apr 10 ];3:217-227
Available from: http://www.jpharmacol.com/article.asp?issn=0976-500X;year=2012;volume=3;issue=3;spage=217;epage=227;aulast=Ghelani;type=0