Journal of Pharmacology and Pharmacotherapeutics

RESEARCH PAPER
Year
: 2013  |  Volume : 4  |  Issue : 4  |  Page : 238--242

Anti-inflammatory activity of calcium channel blocker lercanidipine hydrochloride


Prathap Vasigar, Mounissamy Batmanabane 
 Department of Anatomy, Sri Manakula Vinayagar Medical College and Hospital, Puducherry, India

Correspondence Address:
Mounissamy Batmanabane
7, Main Road, Thiru Nagar, Moolakulam, Puducherry
India

Objective: To evaluate the anti-inflammatory effect of the third-generation CCB, lercanidipine. Materials and Methods: The ability of lercanidipine to reduce inflammation in carrageenan-induced paw edema in rats was evaluated, using different doses and its anti-inflammatory effect was compared with that of diclofenac sodium. Mast cell degranulation effect of lercanidipine was also carried out. Results: Lercanidipine produced a significant reduction in the inflammatory paw edema at all doses and at all intervals (P < 0.001). The percentage of reduction in edema was found to be proportionate to the doses of lercanidipine. Lercanidipine also significantly reduced the percentage of propranolol-induced mast cell degranulation. Conclusions: It was found that lercanidipine exerts a positive anti-inflammatory effect in a dose-dependent manner and was superior to diclofenac sodium.


How to cite this article:
Vasigar P, Batmanabane M. Anti-inflammatory activity of calcium channel blocker lercanidipine hydrochloride.J Pharmacol Pharmacother 2013;4:238-242


How to cite this URL:
Vasigar P, Batmanabane M. Anti-inflammatory activity of calcium channel blocker lercanidipine hydrochloride. J Pharmacol Pharmacother [serial online] 2013 [cited 2019 Aug 21 ];4:238-242
Available from: http://www.jpharmacol.com/article.asp?issn=0976-500X;year=2013;volume=4;issue=4;spage=238;epage=242;aulast=Vasigar;type=0