Journal of Pharmacology and Pharmacotherapeutics

RESEARCH PAPER
Year
: 2014  |  Volume : 5  |  Issue : 3  |  Page : 193--196

Effects of glucocorticoids and tumor necrosis factor-alpha inhibitors on both clinical and molecular parameters in patients with Takayasu arteritis


Raffaele Serra1, Raffaele Grande1, Gianluca Buffone1, Edoardo Scarcello2, Fabio Tripodi3, Pierandrea Rende4, Luca Gallelli4, Stefano de Franciscis1 
1 Department of Medical and Surgical Science, Interuniversity Center of Phlebolymphology, International Research and Educational Program in Clinical and Experimental Biotechnology, Catanzaro, Italy
2 Department of Surgery, Unit of Vascular Surgery, Annunziata Hospital of Cosenza, Cosenza, Italy
3 Department of Pharmacological, Biological and Chemical Science, University of Parma, Parma, Italy
4 Department of Health Science, University Magna Graecia of Catanzaro, Catanzaro, Italy

Correspondence Address:
Luca Gallelli
Department of Health Science, University Magna Graecia of Catanzaro, Viale Europa, Località Germaneto 88100, Catanzaro
Italy

Objective: To explore the effect of sequential treatment with glucocorticoid and tumor necrosis factor-alpha inhibitors in patients with Takayasu arteritis (TA). Materials and Methods: In five patients with TA, the effects of the sequential treatment with prednisone for 5-7 months and then with adalimumab (ADA) + methotrexate (MTX) or infliximab + MTX, or with ADA only, for 12 months on both clinical and laboratory findings were evaluated. Results: All treatments improved both symptoms and laboratory parameters without the development of side-effects. Conclusions: It was hypothesized that MMP-9 and neutrophil gelatinase-associated lipocalin could be markers of the response to the treatments.


How to cite this article:
Serra R, Grande R, Buffone G, Scarcello E, Tripodi F, Rende P, Gallelli L, de Franciscis S. Effects of glucocorticoids and tumor necrosis factor-alpha inhibitors on both clinical and molecular parameters in patients with Takayasu arteritis.J Pharmacol Pharmacother 2014;5:193-196


How to cite this URL:
Serra R, Grande R, Buffone G, Scarcello E, Tripodi F, Rende P, Gallelli L, de Franciscis S. Effects of glucocorticoids and tumor necrosis factor-alpha inhibitors on both clinical and molecular parameters in patients with Takayasu arteritis. J Pharmacol Pharmacother [serial online] 2014 [cited 2019 Dec 15 ];5:193-196
Available from: http://www.jpharmacol.com/article.asp?issn=0976-500X;year=2014;volume=5;issue=3;spage=193;epage=196;aulast=Serra;type=0