Journal of Pharmacology and Pharmacotherapeutics

RESEARCH PAPER
Year
: 2014  |  Volume : 5  |  Issue : 3  |  Page : 197--202

Antidepressant-like effect of a novel 5-HT 3 receptor antagonist N-(benzo[d] thiazol-2-yl)-3-ethoxyquinoxalin-2-carboxamide 6k using rodents behavioral battery tests


Yeshwant Kurhe, Radhakrishnan Mahesh, Thangaraj Devadoss, Deepali Gupta 
 Department of Pharmacy, Birla Institute of Technology and Science, Pilani, Rajasthan, India

Correspondence Address:
Yeshwant Kurhe
Department of Pharmacy, Birla Institute of Technology and Science, Pilani, Rajasthan - 333 031
India

Objective: To investigate the antidepressant-like effect of N-(benzo[d] thiazol-2-yl)-3- ethoxyquinoxalin-2-carboxamide 6k, a 5-hydroxytryptamine type 3 (5-HT 3 ) receptor antagonist using rodents behavioral battery tests. Materials and Methods: 6k screening was performed with behavioral assays for depression-like forced swim test (FST) at several single doses (0.25-4 mg/kg, intraperitoneal injection (i.p.)) to test the potency of 6k, in which 2 and 4 mg/kg doses were found to be most effective and hence, in further behavioral assays including mechanistic model like 5-hydroxytryptophan (5-HTP)-induced head twitches was performed in mice at acute doses of 6k (2 and 4 mg/kg, i.p.). Furthermore, olfactory bulbectomy (OBX), a surgical model-induced behavioral alterations was performed in rats, and the effect of 6k administered orally (2 and 4 mg/kg, p.o.) after subchronic treatment for 14 days starting from day 15 of postsurgery was examined by percent sucrose preference test and modified open field test (OFT). Results: 6k (1, 2, and 4 mg/kg, i.p.) reduced the immobility time and increased the swimming behavior in FST without affecting the baseline locomotor score showing antidepressant-like effect. 5-HTP-induced head twitch response was potentiated by 6k (2 and 4 mg/kg, i.p.), which indicated rise in the serotonergic neurotransmission in the brain. 6k (2 and 4 mg/kg, p.o.) showed anti-anhedonia effect by increasing the sucrose consumption and reversed the behavioral alterations when exposed to modified open field in OBX rats after subchronic treatment for 14 days, thus exhibiting antidepressant-like effect. Conclusion: 6k attenuated the behavioral derangement in rodents-based behavioral battery tests for depression, indicating antidepressant-like potential.


How to cite this article:
Kurhe Y, Mahesh R, Devadoss T, Gupta D. Antidepressant-like effect of a novel 5-HT 3 receptor antagonist N-(benzo[d] thiazol-2-yl)-3-ethoxyquinoxalin-2-carboxamide 6k using rodents behavioral battery tests.J Pharmacol Pharmacother 2014;5:197-202


How to cite this URL:
Kurhe Y, Mahesh R, Devadoss T, Gupta D. Antidepressant-like effect of a novel 5-HT 3 receptor antagonist N-(benzo[d] thiazol-2-yl)-3-ethoxyquinoxalin-2-carboxamide 6k using rodents behavioral battery tests. J Pharmacol Pharmacother [serial online] 2014 [cited 2019 Aug 18 ];5:197-202
Available from: http://www.jpharmacol.com/article.asp?issn=0976-500X;year=2014;volume=5;issue=3;spage=197;epage=202;aulast=Kurhe;type=0