Journal of Pharmacology and Pharmacotherapeutics

RESEARCH PAPER
Year
: 2015  |  Volume : 6  |  Issue : 1  |  Page : 24--29

Antibiotic prophylaxis in the prevention of rebleeding in acute variceal hemorrhage: A randomized trial


Ajit Agarwal, Sathasivam Suresh Kumar, Jagdish Sadasivan, Vikram Kate 
 Department of Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry, India

Correspondence Address:
Vikram Kate
Department of Surgery, JIPMER, Pondicherry - 605 006
India

Objective: To assess the role of antibiotic prophylaxis in the prevention of rebleeding in acute variceal hemorrhage. Materials and Methods: A total of 60 patients who underwent endoscopic therapy for bleeding esophageal varices were randomized into the prophylaxis group and the on-demand group. Patients in the prophylaxis group received antibiotic prophylaxis using intravenous ofloxacin till the patient resumed oral fluids, followed by oral ofloxacin tablet for a total of 7 days. In the on-demand group, antibiotics were used only when infection was evident. Patients were monitored for rebleeding and infection during the hospital stay. Results: A total of 30 patients in the prophylaxis group and 26 patients in the on-demand group were analyzed. The clinical characteristics in both the groups were similar. The Child-Pugh score was around 7 in both the groups. The incidence of infection was 5/30 (16.7%) in the prophylaxis group and 7/26 (26.9%) in the on-demand group (P = 0.52). The incidence of early rebleeding in the prophylaxis vs. the on-demand group was 3 vs. 5 (P = 0.69), and the incidence of late rebleeding was 6 vs. 8 (P = 0.48). The differences were not significant. Conclusion: The present study shows a trend toward lower rate of early and late rebleeding, infection rate and mortality in the prophylaxis group; hence, routine use of antibiotics in all such patients may not be necessary. Further studies with a larger sample size and a longer follow-up period are required to validate the usefulness of antibiotics in these patients.


How to cite this article:
Agarwal A, Kumar SS, Sadasivan J, Kate V. Antibiotic prophylaxis in the prevention of rebleeding in acute variceal hemorrhage: A randomized trial.J Pharmacol Pharmacother 2015;6:24-29


How to cite this URL:
Agarwal A, Kumar SS, Sadasivan J, Kate V. Antibiotic prophylaxis in the prevention of rebleeding in acute variceal hemorrhage: A randomized trial. J Pharmacol Pharmacother [serial online] 2015 [cited 2020 Sep 19 ];6:24-29
Available from: http://www.jpharmacol.com/article.asp?issn=0976-500X;year=2015;volume=6;issue=1;spage=24;epage=29;aulast=Agarwal;type=0