Journal of Pharmacology and Pharmacotherapeutics

MOLECULES OF THE MILLENNIUM
Year
: 2015  |  Volume : 6  |  Issue : 1  |  Page : 53--57

Macitentan: An important addition to the treatment of pulmonary arterial hypertension


Anjan Khadka, Dick B Singh Brashier, Anantharamu Tejus, Ashok Kumar Sharma 
 Department of Pharmacology, Armed Forces Medical College (AFMC), Pune, Maharashtra, India

Correspondence Address:
Anjan Khadka
Department of Pharmacology, Armed Forces Medical College (AFMC), Wanworie, Pune - 411 040, Maharashtra
India

Macitentan is an orphan drug for the treatment of pulmonary arterial hypertension (PAH). Endothelin-1 (ET-1) plays a critical role of pathophysiology of PAH. Macitentan, a new dual endothelin receptor antagonist, has reportedly improved prognosis of PAH patients by delaying the progression of disease. It prevents the binding of ET-1 to both endothelin A (ET A ) and endothelin B (ET B ) receptors. Macitentan displays higher efficacy, lesser adverse effects and drug interactions. It has completed phase III trials in 2012 for treatment of PAH and has been tried for ischemic digital ulcers in systemic sclerosis, recurrent glioblastoma and combination with chemotherapeutic agents against various cancers. Safety data for macitentan were obtained primarily from a placebo-controlled clinical study in 742 patients with PAH. The Food and Drug Administration (FDA) approved the drug on 13 October 2013. It is an important addition to long-term treatment of PAH.


How to cite this article:
Khadka A, Singh Brashier DB, Tejus A, Sharma AK. Macitentan: An important addition to the treatment of pulmonary arterial hypertension.J Pharmacol Pharmacother 2015;6:53-57


How to cite this URL:
Khadka A, Singh Brashier DB, Tejus A, Sharma AK. Macitentan: An important addition to the treatment of pulmonary arterial hypertension. J Pharmacol Pharmacother [serial online] 2015 [cited 2019 Aug 19 ];6:53-57
Available from: http://www.jpharmacol.com/article.asp?issn=0976-500X;year=2015;volume=6;issue=1;spage=53;epage=57;aulast=Khadka;type=0