Journal of Pharmacology and Pharmacotherapeutics

CASE REPORT
Year
: 2016  |  Volume : 7  |  Issue : 1  |  Page : 38--40

Tamoxifen-induced hypertriglyceridemia causing acute pancreatitis


Hemant Kumar Singh, Mahendranath S Prasad, Arun K Kandasamy, Kadambari Dharanipragada 
 Department of Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India

Correspondence Address:
Hemant Kumar Singh
Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry - 605 006
India

Tamoxifen has both antagonistic and agonistic tissue-specific actions. It can have a paradoxical estrogenic effect on lipid metabolism resulting in elevated triglyceride and chylomicron levels. This can cause life-threatening complications like acute pancreatitis. To our knowledge, very few cases of tamoxifen-induced pancreatitis have been reported in the literature. We report a case of severe hypertriglyceridemia and acute pancreatitis following tamoxifen use. A 50-year-old diabetic lady was on tamoxifen (20mg/day) hormonal therapy for breast cancer. Within 3 months of starting therapy, she developed hypertriglyceridemia and acute pancreatitis. Laboratory values include: Serum amylase 778 IU/L, total cholesterol 785 mg/dL, triglycerides 4568 mg/dL and high-density lipoproteins (HDL) 12 mg/dL. Tamoxifen was substituted with letrozole and atorvastatin started. There was a prompt reversal of the adverse effects. Effects on lipid profile must be considered while initiating tamoxifen in predisposed individuals as the consequences are life threatening.


How to cite this article:
Singh HK, Prasad MS, Kandasamy AK, Dharanipragada K. Tamoxifen-induced hypertriglyceridemia causing acute pancreatitis.J Pharmacol Pharmacother 2016;7:38-40


How to cite this URL:
Singh HK, Prasad MS, Kandasamy AK, Dharanipragada K. Tamoxifen-induced hypertriglyceridemia causing acute pancreatitis. J Pharmacol Pharmacother [serial online] 2016 [cited 2019 Dec 9 ];7:38-40
Available from: http://www.jpharmacol.com/article.asp?issn=0976-500X;year=2016;volume=7;issue=1;spage=38;epage=40;aulast=Singh;type=0