Journal of Pharmacology and Pharmacotherapeutics

CASE REPORT
Year
: 2016  |  Volume : 7  |  Issue : 1  |  Page : 41--43

Pioglitazone-induced congestive heart failure and pulmonary edema in a patient with preserved ejection fraction


Vaneet Jearath, Rajan Vashisht, Vipul Rustagi, Sujeet Raina, Rajesh Sharma 
 Department of Medicine, Dr. Rajendra Prasad Government Medical College, Tanda, Himachal Pradesh, India

Correspondence Address:
Sujeet Raina
C-15, Type-V Quarters, Dr. Rajendra Prasad Government Medical College Campus, Tanda - 176 001, Kangra, Himachal Pradesh
India

Pioglitazone-induced heart failure is known in patients with underlying heart disease, but is not well documented in patients with normal left ventricular function. Pioglitazone has been very popular as it is an insulin sensitizer and insulin resistance is prevalent among Indians. Fluid retention exacerbates pre-existing heart failure or precipitates heart failure in a patient with underlying left ventricular dysfunction. However, pathogenesis of heart failure in a patient with normal left ventricular function is not known. Probably it is due to dose-related effect on pulmonary endothelial permeability, rather than alterations in left ventricular mass or ejection fraction. We report a patient who developed congestive heart failure and pulmonary edema with normal left ventricular function within 1 year of starting pioglitazone therapy. We have to be careful in monitoring all possible side effects during followup when patients are on pioglitazone therapy.


How to cite this article:
Jearath V, Vashisht R, Rustagi V, Raina S, Sharma R. Pioglitazone-induced congestive heart failure and pulmonary edema in a patient with preserved ejection fraction.J Pharmacol Pharmacother 2016;7:41-43


How to cite this URL:
Jearath V, Vashisht R, Rustagi V, Raina S, Sharma R. Pioglitazone-induced congestive heart failure and pulmonary edema in a patient with preserved ejection fraction. J Pharmacol Pharmacother [serial online] 2016 [cited 2019 Dec 10 ];7:41-43
Available from: http://www.jpharmacol.com/article.asp?issn=0976-500X;year=2016;volume=7;issue=1;spage=41;epage=43;aulast=Jearath;type=0