Journal of Pharmacology and Pharmacotherapeutics

CASE REPORT
Year
: 2016  |  Volume : 7  |  Issue : 2  |  Page : 112--114

Acute hepatic injury with amphotericin B deoxycholate in an immunocompetent patient


Jamie L Wagner, Allison M Bell 
 Department of Pharmacy Practice, University of Mississippi School of Pharmacy, Jackson, Mississippi, USA

Correspondence Address:
Jamie L Wagner
Department of Pharmacy Practice, University of Mississippi School of Pharmacy, 2500 N State Street, Jackson, Mississippi 39216
USA

Amphotericin B deoxycholate (AmBd) is rarely used due to its adverse effect profile, which includes nephrotoxicity, infusion-related reactions, and hepatotoxicity. The incidence of hepatotoxicity related to AmBd is 18-23%, but the reports of this adverse effect are mainly in immunocompromised patients receiving chemotherapy. We report a case of AmBd-related acute hepatic injury in an immunocompetent male with multiple medical problems. The patient initially had acute hepatic injury likely caused by poor nutritional status and a diagnosis of failure to thrive, but was recovering. He was also diagnosed with bilateral renal fungal mycetomas and received systemic treatment initially with micafungin and then fluconazole after urine cultures returned with the growth of Candida glabrata. Therapy was expanded to systemic AmBd when the fungal balls persisted. The patient subsequently developed hepatic re-injury with 1 dose of AmBd, and the therapy was discontinued. Caution should be exerted when utilizing AmBd in treating patients with previous hepatic injury.


How to cite this article:
Wagner JL, Bell AM. Acute hepatic injury with amphotericin B deoxycholate in an immunocompetent patient.J Pharmacol Pharmacother 2016;7:112-114


How to cite this URL:
Wagner JL, Bell AM. Acute hepatic injury with amphotericin B deoxycholate in an immunocompetent patient. J Pharmacol Pharmacother [serial online] 2016 [cited 2020 Feb 25 ];7:112-114
Available from: http://www.jpharmacol.com/article.asp?issn=0976-500X;year=2016;volume=7;issue=2;spage=112;epage=114;aulast=Wagner;type=0