Journal of Pharmacology and Pharmacotherapeutics

RESEARCH PAPER
Year
: 2017  |  Volume : 8  |  Issue : 1  |  Page : 21--27

Antianginal efficacy and tolerability of ranolazine as an add-on drug to concomitant medications primarily metoprolol in chronic stable angina patients: A prospective, open-label study


Anant Mahaveer Khot1, HV Anuradha2, VS Prakash3, MC Shivamurathy2 
1 Department of Pharmacology, BLDEU's Shri B. M. Patil Medical College and RC, Vijayapura, Bengaluru, Karnataka, India
2 Department of Pharmacology, M. S. Ramaiah Medical College, Bengaluru, Karnataka, India
3 Department of Cardiology, M. S. Ramaiah Medical College, Bengaluru, Karnataka, India

Correspondence Address:
Anant Mahaveer Khot
Department of Pharmacology, BLDEU's Shri B. M. Patil Medical College and RC, Vijayapura - 586 103, Karnataka
India

Objective: To evaluate the efficacy and tolerability of ranolazine as an add-on drug in chronic stable angina patients and the impact of ranolazine on the quality of life in chronic stable angina patients receiving other antianginal medications. Materials and Methods: It was a prospective, open-label, hospital-based study involving 144 patients with chronic stable angina. First group received either metoprolol 12.5 or 25 mg/day or other antianginal medications; if the symptoms persist, the dose of metoprolol was increased to 50 mg/day, and to the second group, ranolazine 500 mg BD or 1 g OD was added along with metoprolol or others if the anginal attacks were not subsiding. The patients were followed up to 6 months with electrocardiography, treadmill test, and quality of life questionnaire. Adverse events were recorded at each visit during the study. Results: There was a statistically significant reduction in weekly anginal frequency (P < 0.001) and improvement in an exercise tolerance in both the groups, but more in the ranolazine group. Adverse events reported were mild, infrequent. Conclusion: Ranolazine is could be used as an add-on drug in chronic angina patients not improved with metoprolol or antianginal medications.


How to cite this article:
Khot AM, Anuradha H V, Prakash V S, Shivamurathy M C. Antianginal efficacy and tolerability of ranolazine as an add-on drug to concomitant medications primarily metoprolol in chronic stable angina patients: A prospective, open-label study.J Pharmacol Pharmacother 2017;8:21-27


How to cite this URL:
Khot AM, Anuradha H V, Prakash V S, Shivamurathy M C. Antianginal efficacy and tolerability of ranolazine as an add-on drug to concomitant medications primarily metoprolol in chronic stable angina patients: A prospective, open-label study. J Pharmacol Pharmacother [serial online] 2017 [cited 2019 Dec 16 ];8:21-27
Available from: http://www.jpharmacol.com/article.asp?issn=0976-500X;year=2017;volume=8;issue=1;spage=21;epage=27;aulast=Khot;type=0