Journal of Pharmacology and Pharmacotherapeutics

RESEARCH PAPER
Year
: 2018  |  Volume : 9  |  Issue : 4  |  Page : 180--185

A novel potential role of Vitamin K2-7 in relieving peripheral neuropathy


Dilip S Mehta1, Yogesh A Dound2, Shashank S Jadhav2, Abhay A Bhave3, Milind Devale4, Ashok D B Vaidya5 
1 Synergia Life Sciences Pvt. Ltd, Mumbai, Maharashtra, India
2 Department of Medical, Synergia Life Sciences Pvt. Ltd, Mumbai, Maharashtra, India
3 Empire Centre Haematology and Oncology Specialty Clinic, Mumbai, Maharashtra, India
4 Department of Medicine, Kokan Hospital, Mumbai, Maharashtra, India
5 Kasturba Health Society Medical Research Center, Mumbai, Maharashtra, India

Correspondence Address:
Yogesh A Dound
Synergia Life Sciences Pvt. Ltd., 6/312, Jogani Industrial Complex, V N Purav Marg, Chunabhatti, Mumbai - 400 022, Maharashtra
India

Objective: To assess the efficacy, tolerability and safety of vitamin K2-7 in patients with peripheral neuropathy (PN). Materials and Methods: This study was conducted in 100 patients with PN suffering from VBD or T2DM. Vitamin K2-7 capsules (200 mcg) were given orally for 8 weeks followed up to the 12th week. Symptoms included tingling and numbness along with weakness, fatigue, and cramps. The intensity of the symptoms of PN was assessed on a Visual Analog Scale (VAS). Results: At baseline, the VAS score was 6–9 for VBD group and 8–10 for T2DM group. After treatment with Vitamin K2-7 by the 12th week, VAS score had reduced to 1–2 in both groups. The decrease was statistically significant (P < 0.0001). Conclusion: For the first time, in larger sample size, it has been shown that Vitamin K2-7, 200 mcg for 8 weeks, has a therapeutic activity for the symptoms of PN in VBD and T2DM. The reduction in symptoms was persistent in spite of de-challenge of Vitamin K2-7. Vitamin K2-7 was also well tolerated by all the patients. Thus, it can be concluded that Vitamin K2-7 has potential therapeutic effects for PN due to VBD or T2DM.


How to cite this article:
Mehta DS, Dound YA, Jadhav SS, Bhave AA, Devale M, Vaidya AD. A novel potential role of Vitamin K2-7 in relieving peripheral neuropathy.J Pharmacol Pharmacother 2018;9:180-185


How to cite this URL:
Mehta DS, Dound YA, Jadhav SS, Bhave AA, Devale M, Vaidya AD. A novel potential role of Vitamin K2-7 in relieving peripheral neuropathy. J Pharmacol Pharmacother [serial online] 2018 [cited 2019 Jul 24 ];9:180-185
Available from: http://www.jpharmacol.com/article.asp?issn=0976-500X;year=2018;volume=9;issue=4;spage=180;epage=185;aulast=Mehta;type=0