Journal of Pharmacology and Pharmacotherapeutics

RESEARCH PAPER
Year
: 2019  |  Volume : 10  |  Issue : 4  |  Page : 126--131

A comparative study of intrathecal isobaric 0.5% bupivacaine and intrathecal isobaric 0.75% ropivacaine in elective lower segment cesarean section


Akshay Kishore Gadre, Kasturi Hossain Bandyopadhyay, Chumki Dutta, Tulsi Nag 
 Department of Anaesthesiology, Medica Superspecialty Hospital, Kolkata, West Bengal, India

Correspondence Address:
Kasturi Hossain Bandyopadhyay
Flat 1, Block 1, First Floor, Shristi Apartment, 63 EM Bypass, Garia, Fartabad, Kolkata . 700 084, West Bengal
India

Objective: To compare the anesthetic efficacy of isobaric 0.75% ropivacaine with isobaric 0.5% bupivacaine in patients undergoing elective lower segment cesarean section (LSCS) under spinal anesthesia (SA) with respect to the nature of sensory block, motor block, and duration of analgesia. Materials and Methods: In this prospective, randomized, double-blinded study, sixty full-term parturients of American Society of Anesthesiologists Grade I–II, aged 20–35 years, scheduled for elective LSCS, were randomized into two groups namely B and R (n = 30). Preoperative medication regimen and anesthesia protocol followed, were uniform for all patients. Patients received 2.5 ml of either local anesthetic agent intrathecally. Hemodynamic parameters, onset and duration of sensory and motor blockade, level achieved, and side effects were compared between the two groups. Postoperative analgesia was assessed using the Visual Analog Scale scoring and also by noting the time of requirement of the first dose of rescue analgesic. Qualitative data were analyzed by Chi-square test and quantitative data were analyzed by independent sample t-test. Results: All the thirty patients in each arm completed the study without any dropouts. Baseline demographic variables, hemodynamic parameters, characteristics of sensory block (onset, time to reach peak sensory level, and duration), postoperative analgesia, and neonatal outcome were similar in both groups. However, intrathecal isobaric 0.75% ropivacaine demonstrated delayed onset (P = 0.005), and a significantly shorter duration (P = 0.001) of motor block. Conclusion: In view of the shorter duration of motor blockade, with similar duration of sensory blockade, hemodynamics, and postoperative analgesia, 0.75% isobaric ropivacaine (18.75 mg) is an efficient and safe alternative to bupivacaine for SA in elective LSCS.


How to cite this article:
Gadre AK, Bandyopadhyay KH, Dutta C, Nag T. A comparative study of intrathecal isobaric 0.5% bupivacaine and intrathecal isobaric 0.75% ropivacaine in elective lower segment cesarean section.J Pharmacol Pharmacother 2019;10:126-131


How to cite this URL:
Gadre AK, Bandyopadhyay KH, Dutta C, Nag T. A comparative study of intrathecal isobaric 0.5% bupivacaine and intrathecal isobaric 0.75% ropivacaine in elective lower segment cesarean section. J Pharmacol Pharmacother [serial online] 2019 [cited 2020 May 27 ];10:126-131
Available from: http://www.jpharmacol.com/article.asp?issn=0976-500X;year=2019;volume=10;issue=4;spage=126;epage=131;aulast=Gadre;type=0