Home
|
About JPP
|
Editorial board
|
Search
|
Ahead of print
|
Current Issue
|
Archives
|
Instructions
|
Subscribe
|
Advertise
|
Contact us
|
Reader Login
Search Article
Advanced search
Users Online: 1061
Export selected to
Endnote
Reference Manager
Procite
Medlars Format
RefWorks Format
BibTex Format
Access statistics : Table of Contents
2014| October-December | Volume 5 | Issue 4
Online since
October 9, 2014
Archives
Previous Issue
Next Issue
Most popular articles
Most cited articles
Show all abstracts
Show selected abstracts
Export selected to
Viewed
PDF
Cited
EDITORIAL
Push, promote or educate…musings of a pharmacologist on drug promotion
Chanolean Shashindran
October-December 2014, 5(4):225-226
DOI
:10.4103/0976-500X.142427
PMID
:25422560
[FULL TEXT]
[PDF]
[Mobile Full text]
[EPub]
[PubMed]
1,846
8,751
-
REVIEW ARTICLE
Management of diabetes in the elderly with canagliflozin: A newer hypoglycemic drug on the horizon
Vishal Sehgal, Sukhminder Jit Singh Bajwa, Rinku Sehgal, John A Consalvo
October-December 2014, 5(4):227-231
DOI
:10.4103/0976-500X.142428
PMID
:25422561
Canagliflozin is the first available oral inhibitor of sodium/glucose cotransporter 2 (SGLT2) in the market. At the outset it sounds excellent for the use in the elderly diabetic population, because of its minimal tendency to cause hypoglycemia. However, the clinician needs to exercise caution as it needs to be dosed renally. The clinician needs to be circumspect about potential drug interactions, especially when there is an underlying chronic kidney disease (CKD) and congestive heart failure (CHF). Also its use is best avoided in people who are predisposed to genital mycotic and urinary tract infections (UTI).
[ABSTRACT]
[FULL TEXT]
[PDF]
[Mobile Full text]
[EPub]
[CITATIONS]
[PubMed]
3,291
3,075
6
MOLECULES OF THE MILLENNIUM
Sofosbuvir: A novel treatment option for chronic hepatitis C infection
Harmeet Kaur Bhatia, Harmanjit Singh, Nipunjot Grewal, Navreet Kaur Natt
October-December 2014, 5(4):278-284
DOI
:10.4103/0976-500X.142464
PMID
:25422576
Hepatitis C currently infects more than 170 million people around the world, leading to significant morbidity and mortality. The current standard of care for HCV infection, including one of the two protease inhibitors, telaprevir or boceprevir, for 12-32 weeks, along with pegylated interferon alfa-2a (PEG-IFN-α) and ribavirin for up to 48 weeks, is unsatisfactory in many cases, either because of lack of efficacy or because of treatment-related adverse effects. There is an urgent need of new drugs with improved efficacy as well as a safety profile. Sofosbuvir, a recently approved nucleotide analog, is a highly potent inhibitor of the NS5B polymerase in the Hepatitis C virus (HCV), and has shown high efficacy in combination with several other drugs, with and without PEG-INF, against HCV. It offers many advantages due to its high potency, low side effects, oral administration, and high barrier to resistance. The efficacy and safety were demonstrated in many large and well-designed phase 2 and phase 3 clinical trials like NEUTRINO, PROTON, ELECTRON, ATOMIC, COSMOS, FUSION, FISSION, NUCLEAR, POSITRON, and the like. It is generally well-tolerated. Adverse events that occurred include: Headache, insomnia, fatigue, nausea, dizziness, pruritis, upper respiratory tract infections, rash, back pain, grade 1 anemia, and grade 4 lymphopenia; however, the exact safety profile can only be judged when this drug is actually used on a large scale.
[ABSTRACT]
[FULL TEXT]
[PDF]
[Mobile Full text]
[EPub]
[CITATIONS]
[PubMed]
4,886
1,067
30
RESEARCH PAPERS
Acetylated and propionated derivatives of swertiamarin have anti-adipogenic effects
Hitesh B Vaidya, Ramesh K Goyal, Sukhinder K Cheema
October-December 2014, 5(4):232-238
DOI
:10.4103/0976-500X.142429
PMID
:25422562
Objective:
To investigate whether the acetylated and propionated derivatives (LMP-09-1 and -2) of swertiamarin have anti-adipogenic effects.
Materials and Methods:
3T3-L1 pre-adipocytes were grown in Dulbecco's Modified Eagle's Medium (DMEM) containing 10% calf serum; fully confluent cells were differentiated with insulin, dexamethasone, and 3-isobutylmethylxanthine in the presence and absence of LMP-09-1 and -2 (100 μg/mL) for 10 days. Control cells received same amount of dimethylsulfoxide (DMSO). On day ten, cells were analyzed for triglycerides accumulation and the expression of genes involved in adipogenesis, lipogenesis, and lipolysis. In another set of experiment, effects of LMP-09-1 and 2 were studied for isoproterenol induced lipolysis using fully mature adipocytes.
Results:
LMP-09-1 and -2 caused a significant (
P
< 0.001) reduction in intracellular triglycerides accumulation. Both LMP-09-1 and -2 significantly (
P
< 0.001) decreased the mRNA expression of peroxisome proliferator activated receptor-γ and acetyl-CoA carboxylase-1, and increased isoproterenol induced lipolysis in adipocytes. LMP-09-1 induced lipolysis even in the absence of isoproterenol, and also showed a significant up-regulation of carnitine palmitoyl transferase-1α and hormone sensitive lipase (HSL) gene expression.
Conclusions:
These findings show that swertiamarin derivatives, LMP-09-1 and -2 have a potent anti-adipogenic effect.
[ABSTRACT]
[FULL TEXT]
[PDF]
[Mobile Full text]
[EPub]
[CITATIONS]
[PubMed]
2,135
1,490
2
Oral carvedilol in escalating doses in the acute treatment of atrial fibrillation
Ravi Venkatachelam Chitrapu, Pentakota Ramana Rao, Gangireddy Venkateswara Reddy
October-December 2014, 5(4):239-244
DOI
:10.4103/0976-500X.142430
PMID
:25422563
Objective:
To study the efficacy of oral carvedilol in acute treatment of atrial fibrillation (AF) with fast ventricular rate.
Materials and Methods:
In an open-label, single-arm trial, oral carvedilol was administered to 35 patients of AF in escalating doses from 3.125 mg o.d. to 12.5 mg b.i.d.
Results:
A successful result was seen in 25 patients (71.4%) with 4 converting to sinus rhythm, rate control to less than 90 bpm in 16 and a 20% rate reduction in 5 patients. Two patients developed hypotension needing withdrawal of the drug.
Conclusion:
Escalating doses of oral carvedilol can be effectively and safely used in the acute treatment of AF with fast ventricular rate.
[ABSTRACT]
[FULL TEXT]
[PDF]
[Mobile Full text]
[EPub]
[PubMed]
2,716
513
-
CASE REPORTS
Cutaneous adverse drug reaction type erythema multiforme major induced by eslicarbazepine
Andreu Massot, Ana Gimenez-Arnau
October-December 2014, 5(4):271-274
DOI
:10.4103/0976-500X.142456
PMID
:25422574
Severe skin reactions occur less frequently with eslicarbazepine (ESL) than with the other aromatic anticonvulsants. We report the first case of cutaneous adverse drug reaction (CADR) to ESL and co-sensitization between ESL and betalactams. A 41-year-old white woman developed focal epilepsy due to a meningioma that was removed. As post-operatory complication, she suffered meningitis as well as a maculo-papular erythema caused by the treatment with meropenem. Subsequently, ESL was started and gradually increased until 800 mg/day. Twenty-five days later, the patient developed an Erythema Multiforme Major (EMM). Strong positive immediate reaction was induced by prick test with carbamazepine (CBZ) and ESL at 0.01 and 0.1% within 15 and 30 minutes; however the delayed reading at 48 hours was negative. The patient was not carrier of the HLA alleles A3101 and B1502 associated with CBZ induced EMM. The hypersensitivity pathogenic mechanism of EMM is unclear and a delayed hypersensitivity process is speculated. However, the patch and intradermal tests in our patient did not show a delayed reaction but an immediate cutaneous one. A first allergic episode may elicit a massive nonspecific activation of the immune system, providing an enhanced expression of co-stimulatory molecules that decreases the level of tolerance to other drugs. When prescribing ESL, we suggest ruling out previous CADR, especially to CBZ and oxcarbazepine but also other chemically unrelated drugs such as beta-lactams.
[ABSTRACT]
[FULL TEXT]
[PDF]
[Mobile Full text]
[EPub]
[CITATIONS]
[PubMed]
2,220
393
8
Leukocytoclastic vasculitis and acute allergic interstitial nephritis following ceftriaxone exposure
Sachin R Agrawal, Atul Rajput, AP Jain
October-December 2014, 5(4):268-270
DOI
:10.4103/0976-500X.142453
PMID
:25422573
Leukocytoclastic vasculitis (LCV), also known as hypersensitivity vasculitis is a small vessel inflammatory disease which mainly involves the postcapillary venules. A 17-year-old girl developed palpable purpura over lower limbs and acute allergic interstitial nephritis 5 days after exposure to ceftriaxone. Skin biopsy from the lesion over lower limbs confirmed the diagnosis of LCV. Discontinuation of drug and treatment with steroid resulted in resolution of skin lesions and normalization of kidney functions. Beta-lactams are commonly used antibiotics in various types of infection in day-to-day practice. LCV, a rare complication of ceftriaxone should be kept in mind while using this drug.
[ABSTRACT]
[FULL TEXT]
[PDF]
[Mobile Full text]
[EPub]
[CITATIONS]
[PubMed]
1,876
344
4
Catatonia in mixed alcohol and benzodiazepine withdrawal
Aniruddha Basu, Amit Jagtiani, Rajiv Gupta
October-December 2014, 5(4):261-264
DOI
:10.4103/0976-500X.142449
PMID
:25422571
Catatonia is mostly caused by different neuropsychiatric conditions. We report a case of a 30 year old man suffering from both alcohol and benzodiazepine dependence who exhibited catatonic features soon after stopping the intake of substances. This case will help clinicians to recognize catatonic features within the varied symptomatology of substance withdrawal and thereby helping in its early diagnosis and management.
[ABSTRACT]
[FULL TEXT]
[PDF]
[Mobile Full text]
[EPub]
[CITATIONS]
[PubMed]
1,884
264
6
CORRESPONDENCE
The impact of irrational practices: A wake up call
Meena Garg, Pinki Vishwakarma, Monica Sharma, Rajiv Nehra, KK Saxena
October-December 2014, 5(4):245-247
DOI
:10.4103/0976-500X.142434
PMID
:25422564
[FULL TEXT]
[PDF]
[Mobile Full text]
[EPub]
[PubMed]
1,786
310
-
CASE REPORTS
Risperidone-induced mania: An emergent complication of treatment
Anjana Rao Kavoor, Sayantanava Mitra, Supriya Kumar Mondal, Basudeb Das
October-December 2014, 5(4):258-260
DOI
:10.4103/0976-500X.142448
PMID
:25422570
The occurrence of manic/hypomanic switch in patients being treated with risperidone has been reported by various authors, and they have described a variety of strategies for their management. In this report, we describe two cases of induction of elevated mood symptoms in patients treated with risperidone. We propose that the emergence of these symptoms may be a complication of treatment with this drug in susceptible individuals, of which the clinicians should be aware, mainly in those diagnosed with schizophrenia and bipolar disorder. We then discuss a few findings that might be useful in the management of such cases. We thereby also propose a mechanism for such an induction.
[ABSTRACT]
[FULL TEXT]
[PDF]
[Mobile Full text]
[EPub]
[CITATIONS]
[PubMed]
1,635
302
2
Ganciclovir-tenofovir interaction leading to tenofovir-induced nephrotoxicity
Radhika Soanker, Shobha Jagdish Chandra Udutha, Malladi VS Subbalaxmi, YSN Raju
October-December 2014, 5(4):265-267
DOI
:10.4103/0976-500X.142452
PMID
:25422572
Viral enteritis is an important gastrointestinal disorder in human immunodeficiency virus (HIV)-infected patients.
Cytomegalovirus
(CMV) is the most common opportunistic agent in these patients. As ganciclovir and tenofovir are the most commonly used drugs for the treatment of CMV and HIV infection, respectively, this case report showcases the potentiality of drug interaction as well as the safety measures to be taken when using these two drugs together in unavoidable situations.
[ABSTRACT]
[FULL TEXT]
[PDF]
[Mobile Full text]
[EPub]
[CITATIONS]
[PubMed]
1,534
284
3
RESEARCH LETTERS
Antimicrobial utilization in multidisciplinary intensive care units of a public tertiary care hospital
Gudapati Bhanu Naga Sireesha, Pramil Tiwari, Satinder Gombar, Sanjay D'Cruz, Atul Sachdev
October-December 2014, 5(4):252-254
DOI
:10.4103/0976-500X.142441
PMID
:25422567
[FULL TEXT]
[PDF]
[Mobile Full text]
[EPub]
[PubMed]
1,309
322
-
Pharmacovigilance and adverse drug reaction reporting perspectives among interns and postgraduates of a teaching hospital
Raghava Sharma, Adithi Kellarai
October-December 2014, 5(4):248-250
DOI
:10.4103/0976-500X.142436
PMID
:25422565
[FULL TEXT]
[PDF]
[Mobile Full text]
[EPub]
[PubMed]
1,228
361
-
CASE REPORTS
Oyster shell calcium induced parotid swelling
Muthiah Palaniappan, Sandhiya Selvarajan, Sureshkumar Srinivasamurthy, Adithan Chandrasekaran
October-December 2014, 5(4):256-257
DOI
:10.4103/0976-500X.142446
PMID
:25422569
A 59 year old female consumer was started on therapy with oyster shell calcium in combination with vitamin D3 and she presented with swelling below the ear, after two doses. She stopped the drug by herself and the swelling disappeared in one day. She started the drug one day after recovery and again she developed the swelling. She was advised to stop the drug with a suggestion to take lemon to enhance parotid secretion and the swelling subsided. Calcium plays major role in salivary secretion and studies have shown reduced parotid secretion in rats, deficient of vitamin D. But in humans involvement of calcium and vitamin D3 in parotid secretion is unknown. However, the patient had no history of reaction though she had previously taken vitamin D3 with calcium carbonate which was not from oyster shell. Hence, we ruled out vitamin D3 in this reaction and suspecting oyster shell calcium as a culprit. This adverse drug reaction (ADR) was assessed using World Health Organization (WHO) causality assessment, Naranjo's and Hartwig severity scales. As per WHO causality assessment scale, the ADR was classified as "certain". This reaction was analyzed as per Naranjo's algorithm and was classified as probable. According to Hartwig's severity scale the reaction was rated as mild. Our case is an example of a mild but rare adverse effect of oyster shell calcium carbonate which is widely used.
[ABSTRACT]
[FULL TEXT]
[PDF]
[Mobile Full text]
[EPub]
[CITATIONS]
[PubMed]
1,317
253
2
NEWS AND VIEWS
Acetaminophen associated with risk of hearing loss: A safety alert
Sangeeta Bhanwra, Kaza Ahluwalia
October-December 2014, 5(4):275-275
DOI
:10.4103/0976-500X.142458
[FULL TEXT]
[PDF]
[Mobile Full text]
[EPub]
1,263
276
-
RESEARCH LETTERS
Pediatric dosing errors due to variable drug formulations
Sumit Mehndiratta
October-December 2014, 5(4):254-255
DOI
:10.4103/0976-500X.142444
PMID
:25422568
[FULL TEXT]
[PDF]
[Mobile Full text]
[EPub]
[CITATIONS]
[PubMed]
1,120
276
1
Evaluation of potassium clavulanate on ethanol consumption and decision making in the model of ethanol dependence in mice
Kshitij S Jadhav, Padmaja A Marathe
October-December 2014, 5(4):250-252
DOI
:10.4103/0976-500X.142439
PMID
:25422566
[FULL TEXT]
[PDF]
[Mobile Full text]
[EPub]
[PubMed]
1,167
222
-
WEBWISE
Mini Manuscript
Jatinder Singh
October-December 2014, 5(4):276-277
DOI
:10.4103/0976-500X.142462
PMID
:25422575
[FULL TEXT]
[PDF]
[Mobile Full text]
[EPub]
[PubMed]
1,001
182
-
Feedback
Subscribe
Sitemap
|
What's New
|
Feedback
|
Disclaimer
© Journal of Pharmacology and Pharmacotherapeutics | Published by Wolters Kluwer -
Medknow
New site online since 10
th
April, 2010