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   2010| July-December  | Volume 1 | Issue 2  
    Online since November 10, 2010

 
 
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METHODS
Blood sample collection in small laboratory animals
S Parasuraman, R Raveendran, R Kesavan
July-December 2010, 1(2):87-93
DOI:10.4103/0976-500X.72350  PMID:21350616
  29,623 4,466 44
SPECIAL ARTICLES
CONSORT 2010 statement: Updated guidelines for reporting parallel group randomised trials
Kenneth F Schulz, Douglas G Altman, David Moher
July-December 2010, 1(2):100-107
DOI:10.4103/0976-500X.72352  PMID:21350618
  2,957 817 72
RESEARCH LETTERS
Comparison of anti-inflammatory activity of serratiopeptidase and diclofenac in albino rats
Shilpa P Jadav, Nilesh H Patel, Tarang G Shah, Maganlal V Gajera, Hiren R Trivedi, Bharat K Shah
July-December 2010, 1(2):116-117
DOI:10.4103/0976-500X.72362  PMID:21350623
  2,792 811 7
MOLECULES OF THE MILLENNIUM
Agomelatine: A novel melatonergic antidepressant
S Manikandan
July-December 2010, 1(2):122-123
DOI:10.4103/0976-500X.72369  PMID:21350627
  2,270 712 1
SPECIAL ARTICLES
Improving bioscience research reporting: The ARRIVE guidelines for reporting animal research
Carol Kilkenny, William J Browne, Innes C Cuthill, Michael Emerson, Douglas G Altman
July-December 2010, 1(2):94-99
DOI:10.4103/0976-500X.72351  PMID:21350617
  2,298 576 46
RESEARCH LETTERS
Aspartame: Sweetener with anti-inflammatory potential?
Sapna Pradhan, UH Shah, AG Mathur, S Sharma
July-December 2010, 1(2):113-114
DOI:10.4103/0976-500X.72357  PMID:21350621
  2,176 446 1
RESEARCH PAPERS
Role of cinnarizine and nifedipine on anticonvulsant effect of sodium valproate and carbamazepine in maximal electroshock and pentylenetetrazole model of seizures in mice
Ranjana I Brahmane, Vikrant V Wanmali, Swanand S Pathak, Kartik J Salwe
July-December 2010, 1(2):78-81
DOI:10.4103/0976-500X.72348  PMID:21350614
Objective: To study the effect of calcium channel blockers (CCBs) cinnarizine and nifedipine on maximal electroshock (MES)-induced and pentylenetetrazole (PTZ)-induced convulsions and also their effect in combination with conventional antiepileptic drugs (CAED). Materials and Methods: For this study, Swiss albino mice were used. Effects of cinnarizine (30 mg/kg), nifedipine (5 mg/kg), sodium valproate (300 mg/kg) and carbamazepine (8 mg/kg) alone and in combination were studied in MES and PTZ seizure models. Abolition of hind limb tonic extension was an index of anticonvulsant activity in MES, while for PTZ seizures, failure to observe even a single episode of tonic spasm for 5 s duration for 1 h was the index. With this, percentage protection was calculated and statistical analysis was carried out using Fisher's exact test (Ovvind Langsrud software, German version). Results: In MES seizures, augmented effects were obtained when cinnarizine was combined with sodium valproate, i.e. 100%. In PTZ-induced seizures, augmented effects were obtained when nifedipine was combined with sodium valproate, i.e. 100%. Thus, cinnarizine added to sodium valproate therapy produces significant protection against MES seizures while nifedipine added to sodium valproate therapy produces significant protection against PTZ seizures. Conclusion: The results provide a lead for potential benefit of adding CCBs to sodium valproate in the treatment of epilepsy, which needs to be explored further.
  1,931 583 -
COMMENTARY
A critical look at the national essential medicines list of India 2003
S Manikandan
July-December 2010, 1(2):75-77
DOI:10.4103/0976-500X.72347  PMID:21350613
  1,776 456 1
REPORTS
Mahatma Gandhi-Doerenkamp Center for Alternatives to Use of Animals in Life Science Education
Mohammad Abdulkader Akbarsha, Shiranee Pereira
July-December 2010, 1(2):108-110
DOI:10.4103/0976-500X.72353  PMID:21350619
  1,668 262 1
RESEARCH PAPERS
Efficacy, safety and cost-effectiveness of insulin sensitizers as add-on therapy in metabolic syndrome in patients with secondary sulfonylurea failure: A comparative study
Rajiv Mahajan, Anita Gupta, Rajinder Singh Gupta, Kapil Gupta
July-December 2010, 1(2):82-86
DOI:10.4103/0976-500X.72349  PMID:21350615
Objectives: Prevalence of metabolic syndrome (MS) is ~25% and it is currently becoming prevalent in children also. India is estimated to have the maximum number of patients of MS in the world. As insulin resistance is an integral part of MS and the rate of secondary sulfonylurea failure (SSUF) is also high, the present study was planned to evaluate the effects of insulin sensitizers as add-on therapy in MS with SSUF. Materials and Methods: An open-label, prospective, randomized study was conducted on 200 patients of MS with SSUF, included according to ATP III criteria, after dividing them into two groups. Group I patients were given pioglitazone 30 mg/day while group II patients were given metformin 1,000 mg/day as add-on therapy to the sulfonylurea already prescribed. Results: Fall in fasting blood glucose, glycosylated hemoglobin and serum triglycerides was higher with metformin, but rise in high-density lipoprotein-cholesterol was higher with pioglitazone. Only metformin caused a significant reduction in body mass index. Significant reduction in waist circumference, systolic blood pressure and diastolic blood pressure was not seen with any therapy. Incremental cost-effective ratio was almost six-times higher with pioglitazone. Conclusion: Among insulin sensitizers, metformin has more favorable, persistent and multifacet effects in MS with SSUF. Studies of longer duration are required for calculating reduction in the mortality and morbidity.
  1,481 424 -
EDITORIAL
The national essential medicines list of India: Time to revise and purge the mistakes
B Gitanjali
July-December 2010, 1(2):73-74
DOI:10.4103/0976-500X.72346  PMID:21350612
  1,277 519 3
POSTGRADUATE CORNER
Data transformation
S Manikandan
July-December 2010, 1(2):126-127
DOI:10.4103/0976-500X.72373  PMID:21350629
  1,102 351 5
RESEARCH LETTERS
Intern doctors' feedback on teaching methodologies in pharmacology
Jaykaran , Nilesh Chavda, Preeti Yadav, ND Kantharia
July-December 2010, 1(2):114-116
DOI:10.4103/0976-500X.72359  PMID:21350622
  1,130 270 6
NEWS AND VIEWS
Microneedles for painless immunization
G Sivagnanam
July-December 2010, 1(2):128-130
  1,019 217 -
REPORTS
Late Professor P N Saxena: A teacher of excellence
Syed Ziaur Rahman, Rahat Ali Khan
July-December 2010, 1(2):111-112
DOI:10.4103/0976-500X.72355  PMID:21350620
  1,017 170 -
CORRESPONDENCE
Valethamate bromide: Conflicting evidence and continuing use
Arun Babu Thirunavukkarasu, Vijayan Sharmila
July-December 2010, 1(2):120-120
DOI:10.4103/0976-500X.72365  PMID:21350626
  835 193 4
Uncovering negative results: Introducing an open access journal "Journal of Pharmaceutical Negative Results"
Vipra Kundoor, KK Mueen Ahmed
July-December 2010, 1(2):118-119
DOI:10.4103/0976-500X.72364  PMID:21350624
  688 194 -
WEB-WISE
Committee on publication ethics
Jatinder Singh
July-December 2010, 1(2):124-125
DOI:10.4103/0976-500X.72371  PMID:21350628
  589 223 -
CORRESPONDENCE
Author's reply
B Gitanjali
July-December 2010, 1(2):120-121
PMID:21350625
  581 139 -
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