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  Indian J Med Microbiol
 

Figure 6: Inhibition of the nifedipine-induced [Ca2+]i elevation by pathway inhibitors. Cells were preincubated with U73122 (10 μM), xestospongin C (2 μM), or SKF-96365 (10 μM) prior to the application of nifedipine (10 μM). Upper panel: representative trace showing the effect of U73122 on the nifedipine-induced [Ca2+]i elevation. Lower panel: effect of nifedipine on [Ca2+]i in the absence (white bars) or presence (hatched bars) of inhibitors. Data are mean ± SEM, N = 12 (U73122), 16 (xestospongin C), or 20 (SKF-96365). ***P < 0.005, ****P < 0.001 compare to corresponding pretreated values

Figure 6: Inhibition of the nifedipine-induced [Ca<sup>2+</sup>]i elevation by pathway inhibitors. Cells were preincubated with U73122 (10 μM), xestospongin C (2 μM), or SKF-96365 (10 μM) prior to the application of nifedipine (10 μM). Upper panel: representative trace showing the effect of U73122 on the nifedipine-induced [Ca2+]i elevation. Lower panel: effect of nifedipine on [Ca<sup>2+</sup>]i in the absence (white bars) or presence (hatched bars) of inhibitors. Data are mean ± SEM, N = 12 (U73122), 16 (xestospongin C), or 20 (SKF-96365). ***<i>P</i> < 0.005, ****P < 0.001 compare to corresponding pretreated values