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  Indian J Med Microbiol
 

Figure 1: Effects of asenapine on nitric oxide release in H9C2. (a) Dose-response and time-course study. (b) Effects of 15 min asenapine (10 pM-100 μM) in peroxidative conditions. (c) Effects of 2 min asenapine (100 nM) in the presence or absence of various agents. A = Asenapine; amlodip = Amlodipine (1 μM); NAD = NAD-299 (1 μM); Nefaz = Nefazodone (1 μM); propionyl = Propionyl promazine (1 μM); ML218 = ML218 (1 μM); 2'5' =2'5' dideoxyadenosine (1 μM): H89 = H89 (1 μM); KN93 = KN93 (1 μM); U73 = U73122 (1 μM); L-NAME = Nω-nitro-L-arginine methyl ester (10 mM). Nitric oxide release is expressed as % in comparison to basal values (c). The results are the mean ± standard deviation of five experiments for each experimental protocol. (c) b, c, e, g, i, m, o, q, s, u, z P < 0.05 versus a; d, f, h, l, n, p, r, t, v, w P < 0.05 versus b

Figure 1: Effects of asenapine on nitric oxide release in H9C2. (a) Dose-response and time-course study. (b) Effects of 15 min asenapine (10 pM-100 μM) in peroxidative conditions. (c) Effects of 2 min asenapine (100 nM) in the presence or absence of various agents. A = Asenapine; amlodip = Amlodipine (1 μM); NAD = NAD-299 (1 μM); Nefaz = Nefazodone (1 μM); propionyl = Propionyl promazine (1 μM); ML218 = ML218 (1 μM); 2'5' =2'5' dideoxyadenosine (1 μM): H89 = H89 (1 μM); KN93 = KN93 (1 μM); U73 = U73122 (1 μM); L-NAME = Nω-nitro-L-arginine methyl ester (10 mM). Nitric oxide release is expressed as % in comparison to basal values (c). The results are the mean ± standard deviation of five experiments for each experimental protocol. (c) b, c, e, g, i, m, o, q, s, u, z<i> P </i>< 0.05 versus a; d, f, h, l, n, p, r, t, v, w<i> P </i>< 0.05 versus b