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  Indian J Med Microbiol
 

Figure 3: Effects of asenapine on cytosolic Ca2+ in H9C2 in the presence or absence of various agents in nonperoxidative conditions. (a-d) A = 2 min asenapine (10 μM). (a and c) C = Basal. (a and b) EGTA = Ethylene glycol tetraacetic acid 50 mM; A23 = A23187 (1 μM); H89 = H89 (1 μM); KN93 = KN93 (1 μM); U73 = U73122 (1 μM); L-NAME = Nω-nitro-L-arginine methyl ester (10 mM). The results are the mean ± standard deviation of five experiments for each experimental protocol. (b and d) The effects of asenapine on Ca2+ in comparison to basal values are reported as %. (a) b, c, e, P < 0.05 versus a; d, f, h, l, n, P P < 0.05 versus b. (b) c, b, d, e, f, g P < 0.05 versus a. (c and d) Amlodip = Amlodipine (1 μM); ML218 = ML218 (1 μM); propionyl = Propionyl promazine (1 μM); Nefaz = Nefazodone (1 μM); NAD = NAD-299 (1 μM). (c) b P < 0.05 versus a; d, f, h, l, n P < 0.05 versus b. (d) b, c, d, e, f P < 0.05 versus a. One-way ANOVA followed by Newman–Keuls post hoc test

Figure 3: Effects of asenapine on cytosolic Ca<sup>2+</sup> in H9C2 in the presence or absence of various agents in nonperoxidative conditions. (a-d) A = 2 min asenapine (10 μM). (a and c) C = Basal. (a and b) EGTA = Ethylene glycol tetraacetic acid 50 mM; A23 = A23187 (1 μM); H89 = H89 (1 μM); KN93 = KN93 (1 μM); U73 = U73122 (1 μM); L-NAME = Nω-nitro-L-arginine methyl ester (10 mM). The results are the mean ± standard deviation of five experiments for each experimental protocol. (b and d) The effects of asenapine on Ca<sup>2+</sup> in comparison to basal values are reported as %. (a) b, c, e,<i> P </i>< 0.05 versus a; d, f, h, l, n,<i> P P</i> < 0.05 versus b. (b) c, b, d, e, f, g<i> P </i>< 0.05 versus a. (c and d) Amlodip = Amlodipine (1 μM); ML218 = ML218 (1 μM); propionyl = Propionyl promazine (1 μM); Nefaz = Nefazodone (1 μM); NAD = NAD-299 (1 μM). (c) b<i> P </i>< 0.05 versus a; d, f, h, l, n<i> P </i>< 0.05 versus b. (d) b, c, d, e, f<i> P </i>< 0.05 versus a. One-way ANOVA followed by Newman–Keuls <i>post hoc</i> test