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  Indian J Med Microbiol
 

Figure 4: Effects of asenapine on cytosolic Ca2+ in H9C2 in presence or absence of Ca2+ chelator and Ca2+ ionophor, intracellular signaling pathways, and nitric oxide synthase inhibitors in nonperoxidative conditions. An example of each experimental protocol is shown. (a) 2 min asenapine (A) with Ca2+ chelator, ethylene glycol tetraacetic acid; (b) with Ca2+ ionophor A23187; (c) with PKA inhibitor, H89; (d) with PLC inhibitor, U73122 (U73); (e) with CaMKII inhibitor, KN93; (f), with nitric oxide synthase inhibitor, Nω-nitro-L-arginine methyl ester. The layout is the same as in Figure 3

Figure 4: Effects of asenapine on cytosolic Ca<sup>2+</sup> in H9C2 in presence or absence of Ca<sup>2+</sup> chelator and Ca<sup>2+</sup> ionophor, intracellular signaling pathways, and nitric oxide synthase inhibitors in nonperoxidative conditions. An example of each experimental protocol is shown. (a) 2 min asenapine (A) with Ca<sup>2+</sup> chelator, ethylene glycol tetraacetic acid; (b) with Ca<sup>2+</sup> ionophor A23187; (c) with PKA inhibitor, H89; (d) with PLC inhibitor, U73122 (U73); (e) with CaMKII inhibitor, KN93; (f), with nitric oxide synthase inhibitor, Nω-nitro-L-arginine methyl ester. The layout is the same as in Figure 3