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  Indian J Med Microbiol
 

Figure 1: (A) Representative traces for IhERG1a (Ai) and IhERG1a/1b (Aii) before and during exposure to 0.1 μM ebastine at 37°C. Lower panels show voltage protocols used. (B) Isochronal concentration-response relationships at 8 min of drug exposure. hERG 1a (circles; IC50 32 nM [confidence interval 24–43 nM]) and hERG 1a/1b (diamonds; IC50 185 nM [confidence interval 114–304 nM]; P < 0.05 vs. 1a) (n = 4–6 cells per concentration), with nHvalues of 0.79 (confidence interval 0.66–0.93) for hERG1a and of 0.67 (confidence interval 0.35–0.97) for hERG 1a/1b

Figure 1: (A) Representative traces for I<sub>hERG1a</sub> (Ai) and I<sub>hERG1a/1b</sub> (Aii) before and during exposure to 0.1 μM ebastine at 37°C. Lower panels show voltage protocols used. (B) Isochronal concentration-response relationships at 8 min of drug exposure. hERG 1a (circles; IC<sub>50 </sub>32 nM [confidence interval 24–43 nM]) and hERG 1a/1b (diamonds; IC<sub>50 </sub>185 nM [confidence interval 114–304 nM]; <i>P</i> < 0.05 vs. 1a) (<i>n</i> = 4–6 cells per concentration), with n<sub>H</sub>values of 0.79 (confidence interval 0.66–0.93) for hERG1a and of 0.67 (confidence interval 0.35–0.97) for hERG 1a/1b