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  Indian J Med Microbiol
 

Figure 2: (A) Representative traces for IhERG1a (Ai) and IhERG1a/1b (Aii) before and during exposure to 1 μM ebastine at 24°C. Lower panels show voltage protocols used. (B) Isochronal concentration-response relationships at 8 min of drug exposure. hERG 1a (circles; IC50 820 nM [confidence interval 0.45–1.5 μM]) and hERG 1a/1b (diamonds; IC50 1.93 μM [confidence interval 1.23–3.02 μM]) showed differences in inhibitory potency (P < 0.05; n = 4–5 cells per concentration) with nHvalues of 0.72 (confidence interval 0.67–1.11) for hERG1a and of 1.19 (confidence interval 0.65–1.73) for hERG 1a/1b

Figure 2: (A) Representative traces for I<sub>hERG1a</sub> (Ai) and I<sub>hERG1a/1b</sub> (Aii) before and during exposure to 1 μM ebastine at 24°C. Lower panels show voltage protocols used. (B) Isochronal concentration-response relationships at 8 min of drug exposure. hERG 1a (circles; IC<sub>50 </sub>820 nM [confidence interval 0.45–1.5 μM]) and hERG 1a/1b (diamonds; IC<sub>50 </sub>1.93 μM [confidence interval 1.23–3.02 μM]) showed differences in inhibitory potency (<i>P</i> < 0.05; <i>n</i> = 4–5 cells per concentration) with n<sub>H</sub>values of 0.72 (confidence interval 0.67–1.11) for hERG1a and of 1.19 (confidence interval 0.65–1.73) for hERG 1a/1b