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Figure 3: (A) Representative traces for I_{hERG1a} (Ai) and I_{hERG1a/1b} (Aii) before and during exposure to 1 μM fluoxetine at 37°C. Lower panels show voltage protocols used. (B) Isochronal concentrationresponse relationships at 3 min of drug exposure. hERG 1a (circles; IC_{50 }1.40 μM [confidence interval 1.20–1.65 μM]) and hERG 1a/1b (diamonds; IC_{50 }1.36 μM [confidence interval 0.99–1.87 μM]) showed similar IC_{50}values (n = 4–6 cells per concentration; P > 0.05), and an apparently modest but statistically insignificant difference in n_{H }: n_{H} = 1.6 (confidence interval 1.17–2.07) for hERG1a and n_{H} = 0.9 (confidence interval 0.64–1.22) for hERG 1a/1b [P > 0.05 for analysis of variance comparison of these values and that for hERG 1b in Figure 6] 
