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  Indian J Med Microbiol
 

Figure 4: (A) Representative traces for IhERG1a (Ai) and IhERG1a/1b (Aii) before and during exposure to 1 μM chloroquine at 37°C. Lower panels show voltage protocols used. (B) Isochronal concentration-response relationships at 3 min of drug exposure for chloroquine inhibition of hERG1a (circles; IC50 0.89 μM [confidence interval 0.63–1.27 μM]) and hERG1a/1b (diamonds; IC50 1.43 μM [confidence interval 1.02–2 μM]) n = 4–7 cells per concentration (P > 0.05 vs. 1a). Hill coefficients yielded from the fit to dose responses curves were nH = 0.75 (confidence interval 0.55–0.93) for hERG1a and nH = 0.81 (confidence interval 0.58–1.05) for hERG 1a1b

Figure 4: (A) Representative traces for I<sub>hERG1a</sub> (Ai) and I<sub>hERG1a/1b</sub> (Aii) before and during exposure to 1 μM chloroquine at 37°C. Lower panels show voltage protocols used. (B) Isochronal concentration-response relationships at 3 min of drug exposure for chloroquine inhibition of hERG1a (circles; IC<sub>50 </sub>0.89 μM [confidence interval 0.63–1.27 μM]) and hERG1a/1b (diamonds; IC<sub>50 </sub>1.43 μM [confidence interval 1.02–2 μM]) <i>n</i> = 4–7 cells per concentration (<i>P</i> > 0.05 vs. 1a). Hill coefficients yielded from the fit to dose responses curves were n<sub>H</sub> = 0.75 (confidence interval 0.55–0.93) for hERG1a and n<sub>H</sub> = 0.81 (confidence interval 0.58–1.05) for hERG 1a1b