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  Indian J Med Microbiol
 

Figure 5: (A) Representative traces for IhERG1a (Ai) and IhERG1a/1b (Aii) before and during exposure to 30 nM cisapride at 37°C. Lower panels show voltage protocols used. (B) Isochronal concentration-response relationships at 5 min drug exposure. hERG 1a (circles; IC50 40.8 nM [confidence interval 26.2–63.7 nM]) and hERG 1a/1b (diamonds; IC50 52.4 nM [confidence interval 33.5–82 nM]) showed similar IC50values (n = 4–10 cells per concentration) (P > 0.05 vs. 1a), with nHvalues of 0.85 (confidence interval 0.47–1.23) for hERG1a and of 0.65 (confidence interval 0.37–0.94) for hERG 1a/1b

Figure 5: (A) Representative traces for I<sub>hERG1a</sub> (Ai) and I<sub>hERG1a/1b</sub> (Aii) before and during exposure to 30 nM cisapride at 37°C. Lower panels show voltage protocols used. (B) Isochronal concentration-response relationships at 5 min drug exposure. hERG 1a (circles; IC<sub>50 </sub>40.8 nM [confidence interval 26.2–63.7 nM]) and hERG 1a/1b (diamonds; IC<sub>50 </sub>52.4 nM [confidence interval 33.5–82 nM]) showed similar IC<sub>50</sub>values (<i>n</i> = 4–10 cells per concentration) (<i>P</i> > 0.05 vs. 1a), with n<sub>H</sub>values of 0.85 (confidence interval 0.47–1.23) for hERG1a and of 0.65 (confidence interval 0.37–0.94) for hERG 1a/1b