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| Year : 2010 | Volume
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| Issue : 2 | Page : 94-99 |
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Improving bioscience research reporting: The ARRIVE guidelines for reporting animal research
Carol Kilkenny1, William J Browne2, Innes C Cuthill3, Michael Emerson4, Douglas G Altman5
1 The National Centre for the Replacement, Refinement and Reduction of Animals in Research, London, United Kingdom
2 School of Veterinary Science, University of Bristol, Bristol, United Kingdom
3 School of Biological Sciences, University of Bristol, Bristol, United Kingdom
4 National Heart and Lung Institute, Imperial College London, United Kingdom
5 Centre for Statistics in Medicine, University of Oxford, Oxford, United Kingdom
| Date of Web Publication | 10-Nov-2010 |
Correspondence Address:
Carol Kilkenny
The National Centre for the Replacement, Refinement and Reduction of Animals in Research, London
United Kingdom
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0976-500X.72351
How to cite this article:
Kilkenny C, Browne WJ, Cuthill IC, Emerson M, Altman DG. Improving bioscience research reporting: The ARRIVE guidelines for reporting animal research. J Pharmacol Pharmacother 2010;1:94-9 |
How to cite this URL:
Kilkenny C, Browne WJ, Cuthill IC, Emerson M, Altman DG. Improving bioscience research reporting: The ARRIVE guidelines for reporting animal research. J Pharmacol Pharmacother [serial online] 2010 [cited 2022 Jan 27];1:94-9. Available from: http://www.jpharmacol.com/text.asp?2010/1/2/94/72351 |
In the last decade the number of bioscience journals has increased enormously, with many filling specialised niches reflecting new disciplines and technologies. The emergence of open-access journals has revolutionised the publication process, maximising the availability of research data. Nevertheless, a wealth of evidence shows that across many areas, the reporting of biomedical research is often inadequate, leading to the view that even if the science is sound, in many cases the publications themselves are not "fit for purpose," meaning that incomplete reporting of relevant information effectively renders many publications of limited value as instruments to inform policy or clinical and scientific practice. [1],[2],[3],[4],[5],[6],[7],[8],[9],[10],[11],[12],[13],[14],[15],[16],[17],[18],[19],[20],[21] A recent review of clinical research showed that there is considerable cumulative waste of financial resources at all stages of the research process, including as a result of publications that are unusable due to poor reporting. [22] It is unlikely that this issue is confined to clinical research. [2],[3],[4],[5],[6],[7],[8],[9],[10],[11],[12],[13],[14],[16],[17],[18],[19],[20]
Failure to describe research methods and to report results appropriately therefore has potential scientific, ethical and economic implications for the entire research process and the reputation of those involved in it. This is particularly true for animal research, one of the most controversial areas of science. The largest and most comprehensive review of published animal research undertaken to date, to our knowledge, has highlighted serious omissions in the way research using animals is reported. [5] The survey, commissioned by the National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs), a UK Government-sponsored scientific organisation, found that only 59% of the 271 randomly chosen articles assessed stated the hypothesis or objective of the study and the number and characteristics of the animals used (i.e., species/strain, sex and age/weight). Most of the papers surveyed did not report using randomisation (87%) or blinding (86%) to reduce bias in animal selection and outcome assessment. Only 70% of the publications that used statistical methods fully described them and presented the results with a measure of precision or variability. [5] These findings are a cause for concern and are consistent with reviews of many research areas, including clinical studies, published in recent years. [2],[3],[4],[5],[6],[7],[8],[9],[10],[11],[12],[13],[14],[15],[16],[17],[18],[19],[20],[21],[22]
 Good Reporting is Essential for Peer Review and to Inform Future Research | |  |
Scrutiny by scientific peers has long been the mainstay of "quality control" for the publication process. The way that experiments are reported, in terms of the level of detail of methods and the presentation of key results, is crucial to the peer review process and, indeed, the subsequent utility and validity of the knowledge base that is used to inform future research. The onus is therefore on the research community to ensure that their research articles include all relevant information to allow in-depth critique and to avoiding duplicating studies and performing redundant experiments. Ideally scientific publications should present sufficient information to allow a knowledgeable reader to understand what was done, why and how and to assess the biological relevance of the study and the reliability and validity of the findings. There should also be enough information to allow the experiment to be repeated. [23] The problem therefore is how to ensure that all relevant information is included in research publications.
| Using Reporting Guidelines Measurably Improves the Quality of Reporting | | |
Evidence provided by reviews of published research suggests that many researchers and peer reviewers would benefit from guidance about what information should be provided in a research article. The CONSORT Statement for randomised controlled clinical trials was one of the first guidelines developed in response to this need. [24],[25] Since publication, an increasing number of leading journals have supported CONSORT as part of their instructions to authors. [26],[27] As a result, convincing evidence is emerging that CONSORT improves the quality and transparency of reports of clinical trials. [28],[29]
Following CONSORT, many other guidelines have been developed-there are currently more than 90 available for reporting different types of health research, most of which have been published in the last ten years (see http://www.equator-network.org and references [30],[31] ). Guidelines have also been developed to improve the reporting of other specific bioscience research areas including metabolomics and gene expression studies. [32],[33],[34],[35],[36],[37] Several organisations support the case for improved reporting and recommend the use of reporting guidelines, including the International Committee of Medical Journal Editors, the Council of Science Editors, the Committee on Publication Ethics and the Nuffield Council for Bioethics. [38],[39],[40],[41]
| Improving the Reporting of Animal Experiments-The ARRIVE Guidelines | | |
Most bioscience journals currently provide little or no guidance on what information to report when describing animal research. [42],[43],[44],[45],[46],[47],[48],[49],[50] Our review found that 4% of the 271 journal articles assessed did not report the number of animals used anywhere in the methods or the results sections. [5] Reporting animal numbers is essential so that the biological and statistical significance of the experimental results can be assessed or the data reanalysed and is also necessary if the experimental methods are to be repeated. Improved reporting of these and other details will maximise the availability and utility of the information gained from every animal and every experiment, preventing unnecessary animal use in the future. To address this, we led an initiative to produce guidelines for reporting animal research. The guidelines, referred to as ARRIVE (Animals in Research: Reporting In vivo Experiments), have been developed using the CONSORT Statement as their foundation. [24],[25]
The ARRIVE guidelines consist of a checklist of 20 items describing the minimum information that all scientific publications reporting research using animals should include, such as the number and specific characteristics of animals used (including species, strain, sex and genetic background); details of housing and husbandry; and the experimental, statistical and analytical methods (including details of methods used to reduce bias such as randomisation and blinding). All the items in the checklist have been included to promote high-quality, comprehensive reporting to allow an accurate critical review of what was done and what was found.
Consensus and consultation are the corner-stones of the guideline development process. [51] To maximise their utility, the ARRIVE guidelines have been prepared in consultation with scientists, statisticians, journal editors and research funders. We convened an expert working group, comprising researchers and statisticians from a range of disciplines and journal editors from Nature Cell Biology, Science, Laboratory Animals and the British Journal of Pharmacology (see Acknowledgments). At a one-day meeting in June 2009, the working group agreed the scope and broad content of a draft set of guidelines that were then used as the basis for a wider consultation with the scientific community, involving researchers and grant holders and representatives of the major bioscience funding bodies including the Medical Research Council, Wellcome Trust, Biotechnology and Biological Sciences Research Council and The Royal Society [Table 1] and [Table 2]. Feedback on the content and wording of the items was incorporated into the final version of the checklist. Further feedback on the content utility of the guidelines is encouraged and sought. | Table 2: Animal research: Reporting in vivo experiments: The ARRIVE guidelines
Click here to view |
| Improved Reporting will Maximise the Output of Published Research | | |
These guidelines were developed to maximise the output from research using animals by optimising the information that is provided in publications on the design, conduct and analysis of the experiments. The need for such guidelines is further illustrated by the systematic reviews of animal research that have been carried out to assess the efficacy of various drugs and interventions in animal models. [8],[9],[13],[52],[53],[54],[55] Well-designed and -reported animal studies are the essential building blocks from which such a systematic review is constructed. The reviews have found that, in many cases, reporting omissions, in addition to the limitations of the animal models used in the individual studies assessed in the review, are a barrier to reaching any useful conclusion about the efficacy of the drugs and interventions being compared. [2],[3]
Driving improvements in reporting research using animals will require the collective efforts of authors, journal editors, peer reviewers and funding bodies. There is no single simple or rapid solution, but the ARRIVE guidelines provide a practical resource to aid these improvements. The guidelines will be published in several leading bioscience research journals simultaneously, [56],[57],[58],[59],[60] and publishers have already endorsed the guidelines by including them in their journal Instructions to Authors subsequent to publication. The NC3Rs will continue to work with journal editors to extend the range of journals adopting the guidelines and with the scientific community to disseminate the guidelines as widely as possible ( http://www.nc3rs.org.uk/ARRIVE ).
| Acknowledgments | | |
The NC3Rs gratefully acknowledges the expertise and advice that all the contributors have given to developing the guidelines. We would particularly like to acknowledge the contribution of the other members of NC3Rs Reporting Guidelines Working Group (note that the working group members and authors who contributed to these guidelines were advising in their personal capacity and their input does not necessarily represent the policy of the organisations with which they are associated): Professor David Balding, Department of Epidemiology and Public Health, Imperial College, London UK; Dr Colin Dunn Editor Laboratory Animals (Royal Society of Medicine press); Dr. Stella Hurtley, Senior Editor Science; Professor Ian McGrath Editor-in-Chief British Journal of Pharmacology (Wiley Blackwell publishers); and Dr. Clare Stanford, Department of Psychopharmacology, University College, London UK. We would also like to thank NC3Rs grant holders, the Medical Research Council, Biotechnology and Biological Sciences Research Council, Wellcome Trust, Parkinson's Disease Society, British Heart Foundation and their grant holders and funding committee members who provided feedback on the guidelines; and Dr. Kathryn Chapman and Dr. Vicky Robinson (both NC3Rs) for their help with the manuscript.
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The role of postnatal estrogen deficiency on cranium dimensions |
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Infliximab and tocilizumab reduce anxiety-like behavior, improve cognitive performance and reverse neuropathological alterations in juvenile rats with severe autoimmune arthritis |
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Trypanosoma cruzi infection in Cyclophilin D deficient mice |
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Granulocyte colony-stimulating factor reduces the endoplasmic reticulum stress in a rat model of diabetic cardiomyopathy |
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Antioxidant, Anti-Inflammatory and Cytotoxic Properties of Centaurea africana Lamk var. [Bonnet] M |
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The Second Oncogenic Hit Determines the Cell Fate of ETV6-RUNX1 Positive Leukemia |
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Galectin-9 Regulates Monosodium Urate Crystal-Induced Gouty Inflammation Through the Modulation of Treg/Th17 Ratio |
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Nerve Growth Factor Enhances Tooth Mechanical Hyperalgesia Through C-C Chemokine Ligand 19 in Rats |
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Sustainable Surface Modification of Polyetheretherketone (PEEK) Implants by Hydroxyapatite/Silica Coating—An In Vivo Animal Study |
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Colonisation Factor CD0873, an Attractive Oral Vaccine Candidate against Clostridioides difficile |
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In Vivo Biological Evaluation of Biodegradable Nanofibrous Membranes Incorporated with Antibiofilm Compounds |
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Quality-Related Properties of Equine Immunoglobulins Purified by Different Approaches |
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Protective Effect and Possible Mechanisms of Astragaloside IV in Animal Models of Diabetic Nephropathy: A Preclinical Systematic Review and Meta-Analysis |
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The Bone Buttress Theory: The Effect of the Mechanical Loading of Bone on the Osseointegration of Dental Implants |
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Different Stages of Alveolar Bone Repair Process Are Compromised in the Type 2 Diabetes Condition: An Experimental Study in Rats |
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Adenosine A2A and A3 Receptors as Targets for the Treatment of Hypertensive-Diabetic Nephropathy |
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Boosting the Intra-Articular Efficacy of Low Dose Corticosteroid through a Biopolymeric Matrix: An In Vivo Model of Osteoarthritis |
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Repurposing FDA Approved Drugs as JNK3 Inhibitor for Prevention of Neuroinflammation Induced by MCAO in Rats |
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The glucosyltransferase activity of C. difficile Toxin B is required for disease pathogenesis |
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The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research |
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Improving translatability of preclinical studies for neuromuscular disorders: lessons from the TREAT-NMD Advisory Committee for Therapeutics (TACT) |
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Reporting guidelines of health research studies are frequently used inappropriately |
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Botulinum toxin A alleviates orofacial nociception induced by orthodontic tooth movement through nociceptin/orphanin-FQ pathway in rats |
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H2S donor GYY4137 ameliorates paclitaxel-induced neuropathic pain in mice |
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Influence of collagen membrane on bone quality in titanium mesh reconstructions—Study in rats |
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Omega-3 offers better hypothalamus protection by decreasing POMC expression and elevating ghrelin hormone: a prospective trial to overcome methotrexate-induced anorexia |
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High Glucose-Aggravated Hepatic Insulin Resistance: Role of the NLRP3 Inflammasome in Kupffer Cells |
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Collagen membranes of dermal and pericardial origin—In vivo evolvement of vascularization over time |
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Generation of a novel mouse strain with fibroblast-specific expression of Cre recombinase |
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High fat diet induced obesity alters endocannabinoid and ghrelin mediated regulation of components of the endocannabinoid system in nodose ganglia |
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Discovery of Potent Dual-Tailed Benzenesulfonamide Inhibitors of Human Carbonic Anhydrases Implicated in Glaucoma and in Vivo Profiling of Their Intraocular Pressure-Lowering Action |
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The effects of oral arginine on its metabolic pathways in Sprague–Dawley rats |
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Effect of dietary supplementation of pyrroloquinoline quinone disodium on growth performance, meat quality and antioxidative ability of broilers |
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A preclinical randomized controlled study of ischemia treated with Ginkgo biloba extracts: Are complex components beneficial for treating acute stroke? |
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Bacterial adhesion inhibitor prevents infection in a rodent surgical incision model |
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| Elizabeth R. Tucker,Jennifer R. Tall,Laura S. Danielson,Sharon Gowan,Yann Jamin,Simon P. Robinson,Udai Banerji,Louis Chesler | | Molecular Oncology. 2017; | | [Pubmed] | [DOI] | | | 229 |
Arthrotomy-based preclinical models of particle-induced osteolysis: A systematic review |
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Taurine, caffeine, and energy drinks: Reviewing the risks to the adolescent brain |
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Animal Models in Translational Research: Rosetta Stone or Stumbling Block? |
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A Series of COX-2 Inhibitors Endowed with NO-Releasing Properties: Synthesis, Biological Evaluation, and Docking Analysis |
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The Versatile 2-Substituted Imidazoline Nucleus as a Structural Motif of Ligands Directed to the Serotonin 5-HT1A
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| Fabio Del Bello,Antonio Cilia,Antonio Carrieri,Domenico Claudio Fasano,Carla Ghelardini,Lorenzo Di Cesare Mannelli,Laura Micheli,Carlo Santini,Eleonora Diamanti,Mario Giannella,Gianfabio Giorgioni,Valerio Mammoli,Corinne Dalila Paoletti,Riccardo Petrelli,Alessandro Piergentili,Wilma Quaglia,Maria Pigini | | ChemMedChem. 2016; 11(20): 2287 | | [Pubmed] | [DOI] | | | 234 |
Repression of telomere-associated genes by microglia activation in neuropsychiatric disease |
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| Golo Kronenberg,Ria Uhlemann,Johanna Schöner,Stephanie Wegner,Valérie Boujon,Nikolas Deigendesch,Matthias Endres,Karen Gertz | | European Archives of Psychiatry and Clinical Neuroscience. 2016; | | [Pubmed] | [DOI] | | | 235 |
Local injection of granulocyte-colony stimulating factor accelerates wound healing in a rat excisional wound model |
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| Guang-Yin Shen,In-Hwa Park,Yi-Sun Song,Hyun-Woo Joo,Yonggu Lee,Jeong-Hun Shin,Kyung-Soo Kim,Hyuck Kim | | Tissue Engineering and Regenerative Medicine. 2016; 13(3): 297 | | [Pubmed] | [DOI] | | | 236 |
Toward more predictive genetic mouse models of Alzheimeræs disease |
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| Kristen D. Onos,Stacey J. Sukoff Rizzo,Gareth R. Howell,Michael Sasner | | Brain Research Bulletin. 2016; 122: 1 | | [Pubmed] | [DOI] | | | 237 |
Preclinical platform of retinoblastoma xenografts recapitulating human disease and molecular markers of dissemination |
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| Guillem Pascual-Pasto,Nagore G. Olaciregui,Monica Vila-Ubach,Sonia Paco,Carles Monterrubio,Eva Rodriguez,Ursula Winter,Mireia Batalla-Vilacis,Jaume Catala,Hector Salvador,Andreu Parareda,Paula Schaiquevich,Mariona Suñol,Jaume Mora,Cinzia Lavarino,Carmen de Torres,Guillermo L. Chantada,Angel M. Carcaboso | | Cancer Letters. 2016; 380(1): 10 | | [Pubmed] | [DOI] | | | 238 |
Development of solid lipid nanoparticles as carriers for improving oral bioavailability of glibenclamide |
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| L.M.D. Gonçalves,F. Maestrelli,L. Di Cesare Manelli,C. Ghelardini,A.J. Almeida,P. Mura | | European Journal of Pharmaceutics and Biopharmaceutics. 2016; 102: 41 | | [Pubmed] | [DOI] | | | 239 |
The a9a10 nicotinic receptor antagonist a-conotoxin RgIA prevents neuropathic pain induced by oxaliplatin treatment |
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| Alessandra Pacini,Laura Micheli,Mario Maresca,Jacopo Juno Valerio Branca,J. Michael McIntosh,Carla Ghelardini,Lorenzo Di Cesare Mannelli | | Experimental Neurology. 2016; 282: 37 | | [Pubmed] | [DOI] | | | 240 |
Guidance on assessing the methodological and reporting quality of toxicologically relevant studies: A scoping review |
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Effect of the SOD mimetic MnL4 on in vitro and in vivo oxaliplatin toxicity: Possible aid in chemotherapy induced neuropathy |
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| Lorenzo Di Cesare Mannelli,Matteo Zanardelli,Ida Landini,Alessandra Pacini,Carla Ghelardini,Enrico Mini,Andrea Bencini,Barbara Valtancoli,Paola Failli | | Free Radical Biology and Medicine. 2016; 93: 67 | | [Pubmed] | [DOI] | | | 242 |
Bone computed tomography mineral content evaluation in chickens: effects of substances in homeopathic concentration |
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| Sergio Canello,Gabriele Gasparini,Patrizio Luisetto,Alessandro Di Cerbo,Fabio Pomerri | | Homeopathy. 2016; 105(1): 92 | | [Pubmed] | [DOI] | | | 243 |
Accounting for reciprocal host–microbiome interactions in experimental science |
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Benzenesulfonamides Incorporating Flexible Triazole Moieties Are Highly Effective Carbonic Anhydrase Inhibitors: Synthesis and Kinetic, Crystallographic, Computational, and Intraocular Pressure Lowering Investigations |
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Orthodontics treatments for managing obstructive sleep apnea syndrome in children: A systematic review and meta-analysis |
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Effects of low-level laser therapy on bone healing of critical-size defects treated with bovine bone graft |
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Agomelatine affects rat suprachiasmatic nucleus neurons via melatonin and serotonin receptors |
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| Jing Yang,Hui Juan Jin,Elisabeth Mocaër,Laure Seguin,Hua Zhao,Benjamin Rusak | | Life Sciences. 2016; 155: 147 | | [Pubmed] | [DOI] | | | 248 |
sec-Butylpropylacetamide (SPD) has antimigraine properties |
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The next step in translational research: lessons learned from the first preclinical randomized controlled trial |
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| Gemma Llovera,Arthur Liesz | | Journal of Neurochemistry. 2016; : n/a | | [Pubmed] | [DOI] | | | 250 |
Histological assessment of hard and soft tissues surrounding a novel ceramic implant: a pilot study in the minipig |
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| Antonio Liñares,Leticia Grize,Fernando Muñoz,Benjamin Evans Pippenger,Michel Dard,Olivier Domken,Juan Blanco-Carrión | | Journal of Clinical Periodontology. 2016; 43(6): 538 | | [Pubmed] | [DOI] | | | 251 |
Interleukin-17 Impairs Salivary Tight Junction Integrity in Sjögren’s Syndrome |
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| L.W. Zhang,X. Cong,Y. Zhang,T. Wei,Y.C. Su,A.C.A. Serrão,A.R.T. Brito,G.Y. Yu,H. Hua,L.L. Wu | | Journal of Dental Research. 2016; 95(7): 784 | | [Pubmed] | [DOI] | | | 252 |
Inhalation anesthesia of rats: influence of the fraction of inspired oxygen on limb ischemia/reperfusion injury |
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Fc-saxatilin, a snake venom disintegrin, suppresses hypoxia-induced vascular leakage by regulating endothelial occludin expression |
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| H.-J. Choi,I. Kwon,N.-E. Kim,J. Kim,S. An,S. Kang,S.-Y. Hong,H. S. Nam,J. H. Heo | | Thrombosis and Haemostasis. 2016; 117(3) | | [Pubmed] | [DOI] | | | 254 |
Neurophenotypes in Airway Diseases. Insights from Translational Cough Studies |
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| Maria G. Belvisi,Mark A. Birrell,Saifudin Khalid,Michael A. Wortley,Rachel Dockry,Julie Coote,Kimberley Holt,Eric Dubuis,Angela Kelsall,Sarah A. Maher,Sara Bonvini,Ashley Woodcock,Jaclyn A. Smith | | American Journal of Respiratory and Critical Care Medicine. 2016; 193(12): 1364 | | [Pubmed] | [DOI] | | | 255 |
Influence of platelet-derived growth factor on osseous remodeling properties of a variable-thread tapered dental implant in vivo |
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| Peer W. Kämmerer,Eik Schiegnitz,Victor Palarie,Michael Dau,Bernhard Frerich,Bilal Al-Nawas | | Clinical Oral Implants Research. 2016; : n/a | | [Pubmed] | [DOI] | | | 256 |
Pectin nanocoating of titanium implant surfaces - an experimental study in rabbits |
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Sustained relief of ongoing experimental neuropathic pain by a CRMP2 peptide aptamer with low abuse potential |
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| Jennifer Y. Xie,Lindsey A. Chew,Xiaofang Yang,Yuying Wang,Chaoling Qu,Yue Wang,Lauren M. Federici,Stephanie D. Fitz,Matthew S. Ripsch,Michael R. Due,Aubin Moutal,May Khanna,Fletcher A. White,Todd W. Vanderah,Philip L. Johnson,Frank Porreca,Rajesh Khanna | | PAIN. 2016; 157(9): 2124 | | [Pubmed] | [DOI] | | | 258 |
Single administration of recombinant IL-6 restores the gene expression of lipogenic enzymes in liver of fasting IL-6-deficient mice |
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| AL Gavito,R Cabello,J Suarez,A Serrano,F J Pavón,M Vida,M Romero,V Pardo,D Bautista,S Arrabal,J Decara,AL Cuesta,A M Valverde,F Rodríguez de Fonseca,E Baixeras | | British Journal of Pharmacology. 2016; 173(6): 1070 | | [Pubmed] | [DOI] | | | 259 |
BN-9, a chimeric peptide with mixed opioid and neuropeptide FF receptor agonistic properties, produces nontolerance-forming antinociception in mice |
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| Ning Li,Zheng-lan Han,Zi-long Wang,Yan-hong Xing,Yu-long Sun,Xu-hui Li,Jing-jing Song,Ting Zhang,Run Zhang,Meng-na Zhang,Biao Xu,Quan Fang,Rui Wang | | British Journal of Pharmacology. 2016; 173(11): 1864 | | [Pubmed] | [DOI] | | | 260 |
Nalmefene is effective at reducing alcohol seeking, treating alcohol-cocaine interactions and reducing alcohol-induced histone deacetylases gene expression in blood |
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| Javier Calleja-Conde,Victor Echeverry-Alzate,Elena Giné,Kora-Mareen Bühler,Roser Nadal,Rafael Maldonado,Fernando Rodríguez de Fonseca,Antoni Gual,Jose Antonio López-Moreno | | British Journal of Pharmacology. 2016; | | [Pubmed] | [DOI] | | | 261 |
Anti-neuropathic effects of Rosmarinus officinalis L. terpenoid fraction: relevance of nicotinic receptors |
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| Lorenzo Di Cesare Mannelli,Laura Micheli,Mario Maresca,Giancarlo Cravotto,Maria Bellumori,Marzia Innocenti,Nadia Mulinacci,Carla Ghelardini | | Scientific Reports. 2016; 6: 34832 | | [Pubmed] | [DOI] | | | 262 |
Magnetic study on biodistribution and biodegradation of oral magnetic nanostructures in the rat gastrointestinal tract |
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| Miguel Martín,Alba Rodríguez-Nogales,Víctor Garcés,Natividad Gálvez,Lucía Gutiérrez,Julio Gálvez,Deyanira Rondón,Mónica Olivares,Jose M. Dominguez-Vera | | Nanoscale. 2016; 8(32): 15041 | | [Pubmed] | [DOI] | | | 263 |
Assessment of the Cancer Risk of the Fat-Grafted Breast in a Murine Model |
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Whatæs a SNP between friends: The influence of single nucleotide polymorphisms on virulence and phenotypes of Clostridium difficile strain 630 and derivatives |
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Effects of the neutrophil elastase inhibitor EL-17 in rat adjuvant-induced arthritis |
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| Lorenzo Di Cesare Mannelli,Laura Micheli,Lorenzo Cinci,Mario Maresca,Claudia Vergelli,Alessandra Pacini,Mark T. Quinn,Maria Paola Giovannoni,Carla Ghelardini | | Rheumatology. 2016; : kew055 | | [Pubmed] | [DOI] | | | 266 |
Neuroprotective Effect of the Marine-Derived Compound 11-Dehydrosinulariolide through DJ-1-Related Pathway in In Vitro and In Vivo Models of Parkinson’s Disease |
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| Chien-Wei Feng,Han-Chun Hung,Shi-Ying Huang,Chun-Hong Chen,Yun-Ru Chen,Chun-Yu Chen,San-Nan Yang,Hui-Min Wang,Ping-Jyun Sung,Jyh-Horng Sheu,Kuan-Hao Tsui,Wu-Fu Chen,Zhi-Hong Wen | | Marine Drugs. 2016; 14(10): 187 | | [Pubmed] | [DOI] | | | 267 |
Minimizing chemotherapy-induced peripheral neuropathy: preclinical and clinical development of new perspectives |
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| Laura Poupon,Nicolas Kerckhove,Julie Vein,Sylvain Lamoine,Nicolas Authier,Jérôme Busserolles,David Balayssac | | Expert Opinion on Drug Safety. 2015; 14(8): 1269 | | [Pubmed] | [DOI] | | | 268 |
Adjuvant Therapy With Sodium Alendronate for the Treatment of Experimental Periodontitis in Rats |
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| Juliano De Almeida,Edilson Ervolino,Luiz Henrique Bonfietti,Vivian Cristina Noronha Novaes,Letícia Helena Theodoro,Leandro Araujo Fernandes,Thiago Marchi Martins,Paula Lazilha Faleiros,Valdir Gouveia Garcia | | Journal of Periodontology. 2015; 86(10): 1166 | | [Pubmed] | [DOI] | | | 269 |
Antineuropathic Profile of N-Palmitoylethanolamine in a Rat Model of Oxaliplatin-Induced Neurotoxicity |
|
| Lorenzo Di Cesare Mannelli,Alessandra Pacini,Francesca Corti,Serena Boccella,Livio Luongo,Emanuela Esposito,Salvatore Cuzzocrea,Sabatino Maione,Antonio Calignano,Carla Ghelardini,Theodore John Price | | PLOS ONE. 2015; 10(6): e0128080 | | [Pubmed] | [DOI] | | | 270 |
Brain-Derived Neurotrophic Factor and Antidepressive Effect of Electroconvulsive Therapy: Systematic Review and Meta-Analyses of the Preclinical and Clinical Literature |
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| M. Polyakova,M. L. Schroeter,B. M. Elzinga,S. Holiga,P. Schoenknecht,E. R. de Kloet,M. L. Molendijk,Lin Lu | | PLOS ONE. 2015; 10(11): e0141564 | | [Pubmed] | [DOI] | | | 271 |
Carbonic anhydrase inhibition for the management of cerebral ischemia:in vivoevaluation of sulfonamide and coumarin inhibitors |
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| Lorenzo Di Cesare Mannelli,Laura Micheli,Fabrizio Carta,Andrea Cozzi,Carla Ghelardini,Claudiu T. Supuran | | Journal of Enzyme Inhibition and Medicinal Chemistry. 2015; : 1 | | [Pubmed] | [DOI] | | | 272 |
Mechanical competence of ovariectomy-induced compromised bone after single or combined treatment with high-frequency loading and bisphosphonates |
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| Maxime Camargos G. V.,Maxime Bhattacharya P.,Maxime van Lenthe G. H.,Maxime Del Bel Cury A. A.,Maxime Naert I.,Maxime Duyck J.,Maxime Vandamme K. | | Scientific Reports. 2015; 5: 10795 | | [Pubmed] | [DOI] | | | 273 |
Uric Acid Produces an Inflammatory Response through Activation of NF-?B in the Hypothalamus: Implications for the Pathogenesis of Metabolic Disorders |
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| Wenjie Lu,Youzhi Xu,Xiaoni Shao,Fabao Gao,Yan Li,Jing Hu,Zeping Zuo,Xue Shao,Liangxue Zhou,Yinglan Zhao,Xiaobo Cen | | Scientific Reports. 2015; 5: 12144 | | [Pubmed] | [DOI] | | | 274 |
A novel snake venom-derived GPIb antagonist, anfibatide, protects mice from acute experimental ischaemic stroke and reperfusion injury |
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| Ting-Ting Li,Man-Li Fan,Shi-Xiang Hou,Xiao-Yi Li,Devin M Barry,Hui Jin,Sheng-Yong Luo,Feng Kong,Lit-Fui Lau,Xiang-Rong Dai,Guo-Hui Zhang,Lan-Lan Zhou | | British Journal of Pharmacology. 2015; 172(15): 3904 | | [Pubmed] | [DOI] | | | 275 |
Peri-implant soft tissue analyses comparing Ti and ZrO2abutments: an animal study on beagle dogs |
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| Juan Blanco,Leticia Caneiro,Antonio Liñares,Pilar Batalla,Fernando Muñoz,Isabel Ramos | | Clinical Oral Implants Research. 2015; : n/a | | [Pubmed] | [DOI] | | | 276 |
Quantification of microcirculatory blood flow: a sensitive and clinically relevant prognostic marker in murine models of sepsis |
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| Claire A. Sand,Anna Starr,Catherine D. E. Wilder,Olena Rudyk,Domenico Spina,Christoph Thiemermann,David F. Treacher,Manasi Nandi | | Journal of Applied Physiology. 2015; 118(3): 344 | | [Pubmed] | [DOI] | | | 277 |
Periodontal ligament-derived cells for periodontal regeneration in animal models: a systematic review |
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| R. Bright,K. Hynes,S. Gronthos,P. M. Bartold | | Journal of Periodontal Research. 2015; 50(2): 160 | | [Pubmed] | [DOI] | | | 278 |
The Metabolic Effects of Consumption of Yellow Cassava (Manihot esculenta Crantz) on Some Biochemical Parameters in Experimental Rats |
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| Nelson Udeme,Polycarp Okafor,Chinedum Eleazu | | International Journal of Toxicology. 2015; 34(6): 559 | | [Pubmed] | [DOI] | | | 279 |
Pyruvate stabilizes electrocardiographic and hemodynamic function in pigs recovering from cardiac arrest |
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| Brandon H Cherry,Anh Q Nguyen,Roger A Hollrah,Arthur G Williams,Besim Hoxha,Albert H Olivencia-Yurvati,Robert T Mallet | | Experimental Biology and Medicine. 2015; 240(12): 1774 | | [Pubmed] | [DOI] | | | 280 |
Reduced ß-amyloid pathology in an APP transgenic mouse model of Alzheimer’s disease lacking functional B and T cells |
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| Claudia Späni,Tobias Suter,Rebecca Derungs,Maria Teresa Ferretti,Tobias Welt,Fabian Wirth,Christoph Gericke,Roger M. Nitsch,Luka Kulic | | Acta Neuropathologica Communications. 2015; 3(1) | | [Pubmed] | [DOI] | | | 281 |
Electrical impedance tomography (EIT) for quantification of pulmonary edema in acute lung injury |
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| Constantin J. C. Trepte,Charles R. Phillips,Josep Solà,Andy Adler,Sebastian A. Haas,Michael Rapin,Stephan H. Böhm,Daniel A. Reuter | | Critical Care. 2015; 20(1) | | [Pubmed] | [DOI] | | | 282 |
Unmanipulated native fat exposed to high-energy diet, but not autologous grafted fat by itself, may lead to overexpression of Ki67 and PAI-1 |
|
| Francisco Claro,Joseane Morari,Luciana R Moreira,Luís O Z Sarian,Glauce A Pinto,Licio A Velloso,Aarão M Pinto-Neto | | SpringerPlus. 2015; 4(1) | | [Pubmed] | [DOI] | | | 283 |
Increased a1-adrenoreceptor activity is required to sustain blood pressure in female rats under food restriction |
|
| Aline Arlindo de Souza,Rodrigo Cunha de Menezes,Aline Rezende Abreu,Glaucy Rodrigues Araujo,Daniela Caldeira Costa,Deoclecio Alves Chianca | | Life Sciences. 2015; 128: 55 | | [Pubmed] | [DOI] | | | 284 |
Widespread pain reliever profile of a flower extract of Tanacetum parthenium |
|
| Lorenzo Di-Cesare Mannelli,Barbara Tenci,Matteo Zanardelli,Anna Maidecchi,Andrea Lugli,Luisa Mattoli,Carla Ghelardini | | Phytomedicine. 2015; 22(7-8): 752 | | [Pubmed] | [DOI] | | | 285 |
Oxaliplatin evokes P2X7-dependent glutamate release in the cerebral cortex: A pain mechanism mediated by Pannexin 1 |
|
| Lorenzo Di Cesare Mannelli,Manuela Marcoli,Laura Micheli,Matteo Zanardelli,Guido Maura,Carla Ghelardini,Chiara Cervetto | | Neuropharmacology. 2015; 97: 133 | | [Pubmed] | [DOI] | | | 286 |
A model of neuropathic pain induced by sorafenib in the rat: Effect of dimiracetam |
|
| Lorenzo Di Cesare Mannelli,Mario Maresca,Carlo Farina,Michael W. Scherz,Carla Ghelardini | | NeuroToxicology. 2015; 50: 101 | | [Pubmed] | [DOI] | | | 287 |
Tail-flick test response in 3×Tg-AD mice at early and advanced stages of disease |
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| Raquel Baeta-Corral,Ruti Defrin,Chagi G. Pick,Lydia Giménez-Llort | | Neuroscience Letters. 2015; 600: 158 | | [Pubmed] | [DOI] | | | 288 |
Research synthesis in veterinary science: Narrative reviews, systematic reviews and meta-analysis |
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| Annette OæConnor,Jan Sargeant | | The Veterinary Journal. 2015; 206(3): 261 | | [Pubmed] | [DOI] | | | 289 |
Mast cells promote blood brain barrier breakdown and neutrophil infiltration in a mouse model of focal cerebral ischemia |
|
| Craig M McKittrick,Catherine E Lawrence,Hilary V O Carswell | | Journal of Cerebral Blood Flow & Metabolism. 2015; 35(4): 638 | | [Pubmed] | [DOI] | | | 290 |
A meta-analysis of efficacy in pre-clinical human stem cell therapies for traumatic brain injury |
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| Janessa Chang,Michael Phelan,Brian J. Cummings | | Experimental Neurology. 2015; 273: 225 | | [Pubmed] | [DOI] | | | 291 |
Micro-CT analysis of the rodent jaw bone micro-architecture: A systematic review |
|
| F. Faot,M. Chatterjee,G.V. de Camargos,Joke Duyck,K. Vandamme | | Bone Reports. 2015; 2: 14 | | [Pubmed] | [DOI] | | | 292 |
Acute and subchronic antinociceptive effects of nociceptin/orphanin FQ receptor agonists infused by intrathecal route in rats |
|
| Laura Micheli,Lorenzo Di Cesare Mannelli,Remo Guerrini,Claudio Trapella,Matteo Zanardelli,Roberto Ciccocioppo,Anna Rizzi,Carla Ghelardini,Girolamo Calò | | European Journal of Pharmacology. 2015; 754: 73 | | [Pubmed] | [DOI] | | | 293 |
In the brain of mice, 3-iodothyronamine (T1AM) is converted into 3-iodothyroacetic acid (TA1) and it is included within the signaling network connecting thyroid hormone metabolites with histamine |
|
| Annunziatina Laurino,Gaetano De Siena,Alessandro Saba,Grazia Chiellini,Elisa Landucci,Riccardo Zucchi,Laura Raimondi | | European Journal of Pharmacology. 2015; 761: 130 | | [Pubmed] | [DOI] | | | 294 |
Intrathecal administration of nociceptin/orphanin FQ receptor agonists in rats: A strategy to relieve chemotherapy-induced neuropathic hypersensitivity |
|
| Laura Micheli,Lorenzo Di Cesare Mannelli,Anna Rizzi,Remo Guerrini,Claudio Trapella,Girolamo Calò,Carla Ghelardini | | European Journal of Pharmacology. 2015; 766: 155 | | [Pubmed] | [DOI] | | | 295 |
A class of sulfonamide carbonic anhydrase inhibitors with neuropathic pain modulating effects |
|
| Fabrizio Carta,Lorenzo Di Cesare Mannelli,Melissa Pinard,Carla Ghelardini,Andrea Scozzafava,Robert McKenna,Claudiu T. Supuran | | Bioorganic & Medicinal Chemistry. 2015; 23(8): 1828 | | [Pubmed] | [DOI] | | | 296 |
Early postnatal handling and environmental enrichment improve the behavioral responses of 17-month-old 3xTg-AD and non-transgenic mice in the Forced Swim Test in a gender-dependent manner |
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| Virginia Torres-Lista,Lydia Giménez-Llort | | Behavioural Processes. 2015; 120: 120 | | [Pubmed] | [DOI] | | | 297 |
Quel modèle murin d’infarctus cérébral choisir pour permettre une recherche translationnelle plus efficace ? |
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| Clément Gakuba,Morgane Louessard,Marina Rubio,Hélène Party,Antonin Doyere,Marine Lerouvillois,Suzanne Goursaud,Jean-Luc Hanouz,Emmanuel Touzé,Véronique Agin,Denis Vivien,Maxime Gauberti | | Anesthésie & Réanimation. 2015; 1: A46 | | [Pubmed] | [DOI] | | | 298 |
Specific targeting of neurotoxic side effects and pharmacological profile of the novel cancer stem cell drug salinomycin in mice |
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| Wolfgang Boehmerle,Hanna Muenzfeld,Andreas Springer,Petra Huehnchen,Matthias Endres | | Journal of Molecular Medicine. 2014; | | [Pubmed] | [DOI] | | | 299 |
Persistence of behaviours in the Forced Swim Test in 3xTg-AD mice at advanced stages of disease |
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| Virginia Torres-Lista,Lydia Giménez-Llort | | Behavioural Processes. 2014; | | [Pubmed] | [DOI] | | | 300 |
Bizarre behaviors and risk assessment in 3xTg-AD mice at early stages of the disease |
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| R. Baeta-Corral,L. Giménez-Llort | | Behavioural Brain Research. 2014; 258: 97 | | [Pubmed] | [DOI] | | | 301 |
Pharmacological and methodological aspects of the separation-induced vocalization test in guinea pig pups; a systematic review and meta-analysis |
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| Lucianne Groenink,P. Monika Verdouw,Brenda Bakker,Kimberley E. Wever | | European Journal of Pharmacology. 2014; | | [Pubmed] | [DOI] | | | 302 |
Cell type–specific mRNA purification by translating ribosome affinity purification (TRAP) |
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| Myriam Heiman,Ruth Kulicke,Robert J Fenster,Paul Greengard,Nathaniel Heintz | | Nature Protocols. 2014; 9(6): 1282 | | [Pubmed] | [DOI] | | | 303 |
Improving standards for reporting studies involving humans and experimental animals in the British Journal of Nutrition and in the Journal of Nutritional Science |
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Assessment of three approaches for regulatory decision making on pesticides with endocrine disrupting properties |
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