Table of Contents  
Year : 2011  |  Volume : 2  |  Issue : 4  |  Page : 311  

Peels to peel bad cholesterol

Section Editor, JPP, India

Date of Web Publication12-Oct-2011

Correspondence Address:
G Sivagnanam
Professor of Pharmacology, Indira Gandhi Medical College and Research Institute, Kadhirkamam, Puducherry
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Source of Support: None, Conflict of Interest: None

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How to cite this article:
Sivagnanam G. Peels to peel bad cholesterol. J Pharmacol Pharmacother 2011;2:311

How to cite this URL:
Sivagnanam G. Peels to peel bad cholesterol. J Pharmacol Pharmacother [serial online] 2011 [cited 2021 May 14];2:311. Available from:

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"Compound found in the peels of citrus fruit can potentially lower cholesterol more effectively than prescription drugs, and without side effects, according to a study by U.S. and Canadian researchers". [1]

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Polymethoxylated flavones (PMFs) are plant pigments found in the peels of citrus fruits which have been related to protect against cancer, heart disease and inflammation. The most common citrus PMFs, tangeretin and nobiletin, are found in the peels of tangerines and oranges. It has been shown that feeding hypercholesterolemic hamsters with food containing 1% PMFs (tangeretin, or citrus flavanone glucosides, hesperidin and naringin) lowered LDL levels by up to 40%. It is thought to act by inhibiting cholesterol and triglyceride synthesis in the liver. [2] It is estimated that a person needs >20 cups/day (~3-4liters) of orange or tangerine juice to have a therapeutic effect. PMF supplements may be the answer.

PMFs supplement is available in the U.S., marketed as a cholesterol-lowering agent under the trade name Sytrinol. Although the website states, [3] "The cardio-protective and cholesterol-lowering claims for Sytrinol™ are also supported by human trials", there is no published evidence to substantiate.

   References Top

1.Available from: [Last accessed on 2011 June 16].  Back to cited text no. 1
2.Kurowska EM, Manthey JA. Hypolipidemic effects and absorption of citrus polymethoxylated flavones in hamsters with diet-induced hypercholesterolemia. J Agric Food Chem 2004;52:2879-86.  Back to cited text no. 2
3.New dietary supplement shows dramatic effects in lowering cholesterol, LDL, and triglycerides. Available from: [Last accessed on 2011 June 17].  Back to cited text no. 3


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