Year : 2012  |  Volume : 3  |  Issue : 1  |  Page : 39-42

Acute effects of granulocyte colony-stimulating factor on early ventricular arrhythmias after coronary occlusion in rats

Department of Physiological Sciences, Federal University of Espírito Santo, Vitória, ES, Brazil

Correspondence Address:
Marcelo Perim Baldo
Department of Physiological Sciences, Federal University of Espirito Santo, Av. Marechal Campos, 1468 - 29042-751, Vitoria, ES
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Source of Support: Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) and Fundação de Amparo a Pesquisa do Espírito Santo (FAPES/PRONEX), Conflict of Interest: None

DOI: 10.4103/0976-500X.92508

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Objectives: To evaluate the acute effects of colony-stimulating factor (G-CSF) on ventricular arrhythmias after coronary occlusion in rats. Materials and Methods: Male Wistar rats (10 weeks) received G-CSF (100 μ -1 ) or vehicle. Thirty minutes later, animals were infarcted by coronary occlusion under artificial respiration. Electrocardiogram was monitored for 30 min to evaluate ventricular arrhythmias. Results: G-CSF treatment reduced the number of premature ventricular beats and the number and duration of ventricular tachycardia. The incidence of ventricular fibrillation was significantly reduced by G-CSF (MI-Cont: 11.2 ± 2.4 vs. MI-GCSF: 5.4 ± 1 events; P < 0.05). However, total duration of ventricular fibrillation was not altered (MI-Cont: 84 ± 16 vs. MI-GCSF: 76 ± 13 sec). Conclusions: Acute administration of G-CSF before coronary ligature in rats reduces the incidence of ventricular premature beats and ventricular tachycardia, suggesting a possible direct electrophysiological effect of this cytokine independently of its genomic effects. However, the data suggest that G-CSF treatment may affect the spontaneous recovery from ventricular fibrillation. Acute G-CSF administration acts directly on cardiac electrophysiology, different from chronic treatment.

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