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Carbamazepine-induced erythema multiforme major in an epileptic patient with bipolar affective disorder
Suneet K Upadhyaya1, Rangeel S Raina2, Archana Sharma3, Vijay Thawani2, Deepak Dimari4
1 Department of Psychiatry, VCSG Govt. Medical Science and Research Institute, Srinagar Garhwal, Uttarakhand, India
2 Department of Pharmacology, VCSG Govt. Medical Science and Research Institute, Srinagar Garhwal, Uttarakhand, India
3 Department of Obstetrics and Gynaecology, VCSG Govt. Medical Science and Research Institute, Srinagar Garhwal, Uttarakhand, India
4 Department of Dermatology, VCSG Govt. Medical Science and Research Institute, Srinagar Garhwal, Uttarakhand, India
Correspondence Address:
Suneet K Upadhyaya
S/o Shri Ashok Kumar Upadhyaya, Prankur, Opposite Idgaah, Kothun Road, Lalsot - 303 503, Dausa, Rajasthan
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0976-500X.95537
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Carbamazepine (CBZ) is frequently used for epilepsy and various psychiatric illnesses. It is known for its dermatological side effects which may range from mild rash to life-threatening reactions as Stevens Johnson syndrome or toxic epidermal necrolysis. We hereby report a rare case of 17-year-old woman suffering from generalized tonic clonic epilepsy with comorbid bipolar affective disorder, who was initially treated with sodium valproate with partial improvement. After 19 days of addition of CBZ to the therapy, the patient developed erythema multiforme major with >60% skin involvement and oral, conjunctival, intestinal, and vaginal mucosal involvement. |
