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| NEWS AND VIEWS |
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| Year : 2012 | Volume
: 3
| Issue : 4 | Page : 350 |
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One more option to void
G Sivagnanam
Department of Pharmacology, Indira Gandhi Medical College and Research Institute, Kadhirkamam, Puducherry, India
| Date of Web Publication | 24-Nov-2012 |
Correspondence Address:
G Sivagnanam
Department of Pharmacology, Indira Gandhi Medical College and Research Institute, Kadhirkamam, Puducherry
India
 Source of Support: None, Conflict of Interest: None  | Check |
How to cite this article:
Sivagnanam G. One more option to void. J Pharmacol Pharmacother 2012;3:350 |
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A possible new target for diuretic therapy in patients with fluid overload, the inhibition of the chloride-absorbing transporter pendrin, and the NaCl co-transporter (NCC) may provide an effective diuretic regimen, research suggests. [1]
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Pendrin is a protein involved in chloride/iodide transport in many cell types - nephrons of the kidney, follicular cells of thyroid and inner ear. Mutations of the gene responsible for pendrin may lead to diseases such as "Pendred syndrome" characterized by deafness, hypothyroidism, and vestibular weakness. [2]
Pendrin is expressed on the cells of distal convoluted tubule and the collecting duct. It is involved in Cl-/HCO 3 - exchange (mediates HCO 3 - secretion and Cl- absorption) and has been demonstrated to play an important role in compensatory salt absorption in response to thiazide and loop diuretics. It has been proposed that pharmacological inhibition of pendrin and thiazide-sensitive NaCl co-transporter can provide a novel and strong diuretic regimen in fluid overload conditions such as congestive heart failure, nephrotic syndrome, etc. [3]
Pendrin production and function are upregulated in conditions with increased circulating aldosterone or angiotensin II (cardiac failure, hypertension). Aldosterone and angiotensin II are thought to modulate the renal regulation of blood pressure, in part, by regulating pendrin-mediated Cl - absorption and epithelial Na + channel (ENaC)-mediated Na + absorption. [4]
Inhibition of pendrin seems yet another option to mobilize edema fluid apart from the existing diuretics.
| References | | |
| 1. | Available from: http://www.news-medical.net/news/20120806/Pendrin-a-possible-new-target-for-diuretic-therapy.aspx. [Last accessed 2012 Aug 14]. 
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| 2. | Available from: http://www.nidcd.nih.gov/health/hearing/pages/pendred.aspx. [Last accessed 2012 Aug 14].
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| 3. | Amlal H, Soleimani M. Pendrin as a novel target for diuretic therapy. Cell Physiol Biochem 2011;28:521-6.
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| 4. | Wall SM, Pech V. Pendrin and sodium channels: Relevance to hypertension. J Nephrol 2010;23:S118-23.
[PUBMED] |
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