Year : 2013  |  Volume : 4  |  Issue : 5  |  Page : 29-32

Abatacept in psoriatic arthritis: Case report and short review

1 Rheumatology Research Unit, Department of Medical and Surgical Sciences, Catanzaro, Italy
2 Department of Health Science, School of Medicine, University of Catanzaro "Magna Gr'cia", Viale Europa, Catanzaro, Italy

Correspondence Address:
Francesco Ursini
Rheumatology Research Unit, Department of Medical and Surgical Sciences, University of Catanzaro "Magna Gr'cia", Viale Europa, Catanzaro 88100
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0976-500X.120943

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Psoriatic arthritis (PsA) is a chronic inflammatory disease affecting about 6-10% of patients with cutaneous psoriasis. According to current knowledge, activated T-cells seem to play a pivotal role in the pathogenesis of both psoriasis and PsA. Abatacept is a novel biologic agent selectively designed to interfere with T-cells co-stimulation. Structurally, it is a soluble, fully human fusion protein consisting of the extracellular domain of CTLA-4 (Cytotoxic T-Lymphocyte Antigen 4) linked to a modified Fc portion of human IgG1. Abatacept is now approved as a first-line treatment for rheumatoid arthritis (RA), but preliminary data disclose a potential role of abatacept in the treatment of other autoimmune diseases. In this article, we report a case of successful treatment with abatacept of a psoriatic arthritis patients who developed adverse drug reactions (ADRs) to medication commonly used in PsA, including three different anti-TNF-α agents. In addition, we review the scientific evidences supporting a possible role of abatacept in treatment of patients with psoriasis and PsA and the paradox of abatacept-induced psoriasis.

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