Year : 2013  |  Volume : 4  |  Issue : 5  |  Page : 38-42

Anti-vascular endothelial growth factor drugs safety and efficacy in ophthalmic diseases

1 Department of Science of Health, School of Medicine; Department of Science of Health, Pharmacovigilance's Centre Calabria Region, University Hospital Mater Domini, Catanzaro, Italy
2 Department of Pharmacy Unit, Giovanni Paolo II Hospital, Lamezia Terme, Italy
3 Department of Oncology Unit, Giovanni Paolo II Hospital, Lamezia Terme, Italy
4 Department of Ophthalmology, University of "Magna Graecia", Catanzaro, Italy

Correspondence Address:
Vincenzo Scorcia
Department of Ophthalmology, School of Medicine, University of Catanzaro, Viale Europa-Germaneto, 88100 Catanzaro
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0976-500X.120947

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Macular degeneration is the leading cause of blindness in developed countries. In the treatment of neovascular age-related macular degeneration, vascular endothelial growth factor (VEGF) has emerged as a key target for therapy. The intravitreal injection of anti-VEGF drugs has been widely employed to reduce the disease progression and improve the visual outcomes of the affected patients. However, each intravitreal inoculation poses a risk of several complications as infection, inflammation, endophthalmitis, intraocular inflammation, increase of intraocular pressure and vitreous hemorrhage. This short review evaluates the efficacy and the incidence of adverse drug reactions related to intravitreal administration of the main anti-VEGF drugs actually available: Bevacizumab, ranibizumab and aflibercept.

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