Year : 2014  |  Volume : 5  |  Issue : 1  |  Page : 33-38

Nephrotoxicity of cefepime: A new cephalosporin antibiotic in rats

1 Department of Pharmacology, Faculty of Veterinary Medicine, Benha University, Egypt
2 Department of Pathology, Faculty of Veterinary Medicine, Benha University, Egypt

Correspondence Address:
Mossad Gamaleddin Ahmed Elsayed
Department of Pharmacology, Faculty of Veterinary Medicine, Benha University
Login to access the Email id

Source of Support: My research project was fully sponsored by Faculty of Veterinary Medicine, Benha University, Egypt, as I am working as assistant lecturer in this university,, Conflict of Interest: None

DOI: 10.4103/0976-500X.124419

Rights and Permissions

Objectives: To investigate the nephrotoxic effect and biochemical alterations induced by cefepime in rats. Materials and Methods: Cefepime was administered intramuscularly at doses of 45, 90 and 180 mg/kg b.wt. once daily for 5 consecutive days. The serum and urine samples were used for quantitative determination of urea, creatinine, glucose, total protein, calcium, sodium and potassium. The histopathological examination of kidney tissues was performed 1, 4 and 8 days after the last dose of cefepime administration. Results: Cefepime induced a significant increase in the total amount of urine per day, urea and creatinine concentration in the serum and urine and significant decrease in their clearance. Cefepime also caused a significant gluocosuria and proteinuria and significant decrease in their serum concentrations. The effect of cefepime on serum and urine concentrations of calcium, sodium and potassium were also determined. Cefepime injection in the three tested doses caused renal tubular, glomerular and vascular changes. The severity of these changes was dose dependent. In conclusion, these results suggest a possible contribution of cefepime in the nephrotoxicity and biochemical alterations, especially at high doses. Therefore, the renal functions should be monitored during the cefepime therapy.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded641    
    Comments [Add]    
    Cited by others 7    

Recommend this journal